Effect of Citrullus colocynthis on glycemic factors and lipid profile in type II diabetic patients: a systematic review and meta-analysis.

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2022-12-01 DOI:10.1007/s40200-022-01045-9

Ali Jafarizadeh, Seyed Amin Raeisi, Nafiseh Ghassab-Abdollahi, Reza Yarani, Mostafa Araj-Khodaei, Mojgan Mirghafourvand

{"title":"Effect of Citrullus colocynthis on glycemic factors and lipid profile in type II diabetic patients: a systematic review and meta-analysis.","authors":"Ali Jafarizadeh, Seyed Amin Raeisi, Nafiseh Ghassab-Abdollahi, Reza Yarani, Mostafa Araj-Khodaei, Mojgan Mirghafourvand","doi":"10.1007/s40200-022-01045-9","DOIUrl":null,"url":null,"abstract":"Purpose: In this systematic review and meta-analysis, we investigated the effect and side effects of Citrullus colocynthis on glycemic factors and lipid profile in diabetic patients.Methods: We systematically searched English and Persian databases from inception till August 2021 using Medical Subject Headings (MeSH). Two authors independently extracted data and assessed the quality of studies. The standardized mean differences were pooled using fixed-effect models, and statistical heterogeneity was assessed using the I squared (I²) index.Results: Of the 321 articles searched in the databases, 136 related articles were screened, 14 relevant full-text articles were assessed for eligibility; finally, four articles were included in the study, three articles were entered into the meta-analysis. The results of the meta-analysis indicated that Citrullus colocynthis does not have a significant effect on fasting blood sugar (FBS), hemoglobin A1c (HBA1c), low-density lipoprotein (LDL), total cholesterol, and triglyceride indices but increases high-density lipoprotein (HDL) (Mean Difference: 5.76; 95% CI: 1.69 to 9.84; P = 0.006; I2 = 0%).Conclusions: The meta-analysis results showed that Citrullus colocynthis has no significant effect on glycemic and metabolic indices of diabetes - except HDL. Due to the relatively low quality and the small number of included trials, conducting further large scale well-designed randomized clinical trials to determine the effect of Citrullus colocynthis on glycemic and metabolic indices seems essential.Supplementary information: The online version contains supplementary material available at 10.1007/s40200-022-01045-9.","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672250/pdf/40200_2022_Article_1045.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes and Metabolic Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40200-022-01045-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 1

Abstract

Purpose: In this systematic review and meta-analysis, we investigated the effect and side effects of Citrullus colocynthis on glycemic factors and lipid profile in diabetic patients.

Methods: We systematically searched English and Persian databases from inception till August 2021 using Medical Subject Headings (MeSH). Two authors independently extracted data and assessed the quality of studies. The standardized mean differences were pooled using fixed-effect models, and statistical heterogeneity was assessed using the I squared (I²) index.

Results: Of the 321 articles searched in the databases, 136 related articles were screened, 14 relevant full-text articles were assessed for eligibility; finally, four articles were included in the study, three articles were entered into the meta-analysis. The results of the meta-analysis indicated that Citrullus colocynthis does not have a significant effect on fasting blood sugar (FBS), hemoglobin A1c (HBA1c), low-density lipoprotein (LDL), total cholesterol, and triglyceride indices but increases high-density lipoprotein (HDL) (Mean Difference: 5.76; 95% CI: 1.69 to 9.84; P = 0.006; I² = 0%).

Conclusions: The meta-analysis results showed that Citrullus colocynthis has no significant effect on glycemic and metabolic indices of diabetes - except HDL. Due to the relatively low quality and the small number of included trials, conducting further large scale well-designed randomized clinical trials to determine the effect of Citrullus colocynthis on glycemic and metabolic indices seems essential.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-022-01045-9.

查看原文本刊更多论文

枸橼酸对II型糖尿病患者血糖因子和血脂的影响:一项系统综述和荟萃分析。

目的:在本系统综述和荟萃分析中，我们研究了甜瓜多糖对糖尿病患者血糖因子和血脂的影响和副作用。方法:我们使用医学主题词(MeSH)系统地检索了英文和波斯语数据库，从创建到2021年8月。两位作者独立提取数据并评估研究质量。使用固定效应模型合并标准化平均差异，并使用I²指数评估统计异质性。结果:在检索到的321篇文献中，筛选了136篇相关文献，评估了14篇相关全文文章的入选资格;最后，四篇文章被纳入研究，三篇文章被纳入meta分析。荟萃分析结果显示，香瓜多糖对空腹血糖(FBS)、血红蛋白A1c (HBA1c)、低密度脂蛋白(LDL)、总胆固醇和甘油三酯指标无显著影响，但可使高密度脂蛋白(HDL)升高(平均差值:5.76;95% CI: 1.69 ~ 9.84;p = 0.006;i2 = 0%)。结论:荟萃分析结果显示，除HDL外，瓜泥对糖尿病的血糖和代谢指标均无显著影响。由于纳入的试验质量相对较低，数量较少，进一步开展大规模、设计良好的随机临床试验，以确定香瓜多糖对血糖和代谢指标的影响似乎是必要的。补充资料:在线版本提供补充资料，网址为10.1007/s40200-022-01045-9。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.