Baseline inflammation indexes and neutrophil-to-LDH ratio for prediction of the first mobilization failure without plerixafor-based regimens in multiple myeloma and lymphoma patients: A single-center retrospective study

IF 1.4 4区医学 Q4 HEMATOLOGY

Journal of Clinical Apheresis Pub Date : 2023-08-14 DOI:10.1002/jca.22085

Ahmet Burak Dirim MD, Tarik Onur Tiryaki MD, Soner Altin MD, Sevgi Kalayoglu Besisik MD, Ipek Yonal Hindilerden MD, Meliha Nalcaci MD

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引用次数: 0

Abstract

Background

Many factors were identified for mobilization failure (MF) in autologous hematopoietic stem-cell transplantation. To our knowledge, this is the first study to investigate the efficacy of baseline inflammation indexes and neutrophil-to-lactate dehydrogenase (LDH) ratio to predict MF in multiple myeloma (MM) and lymphoma.

Methods

A total of 240 patients with lymphoma or MM hospitalized between January 2014 and June 2022 for the first stem cell mobilization were included in this retrospective single-center study. We evaluated the impact of baseline demographic, clinical, and laboratory data (before granulocyte colony-stimulating factor and chemotherapy implementation), including neutrophil, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), neutrophil-to-C-reactive protein, and neutrophil-to-LDH ratios on MF.

Results

A total of 240 patients were divided into successful (214 patients, 89.16%) and poor mobilizers (26 patients, 10.84%). Poor mobilizers had lower neutrophil, NLR, SII, and neutrophil-to-LDH ratios (P values were .001, .022, .001, and .001, respectively). Among these markers, only the neutrophil-to-LDH ratio was statistically low in both poor mobilizer MM and lymphoma patients. Receiving operator characteristic curve analysis was performed to evaluate neutrophil, SII, and neutrophil-to-LDH ratios for MF. Neutrophil-to-LDH ratio had the highest specificity (93.93%, for ≤9.904 cut-off) compared to the other two variables. Multivariate logistic regression analysis showed that neutrophil-to-LDH ratio ≤ 9.904 (cut-off) (odds ratio: 7.116, P = .001), neutrophil counts ≤3300/mm³ (cut-off) (odds ratio: 3.248, P = .021), and lymphoma diagnosis (odds ratio: 2.674, P = .039) were independent risks for MF.

Conclusion

The neutrophil-to-LDH ratio could be a novel marker in lymphoma and MM patients to predict the first MF. New studies should be conducted for the optimization of this index.

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基线炎症指数和中性粒细胞与LDH比值用于预测多发性骨髓瘤和淋巴瘤患者在未使用普利沙佛治疗方案的情况下首次动员失败：单中心回顾性研究

背景在自体造血干细胞移植中，许多因素导致动员失败(MF)。据我们所知，这是第一个研究基线炎症指标和中性粒细胞与乳酸脱氢酶(LDH)比值预测多发性骨髓瘤(MM)和淋巴瘤MF疗效的研究。方法选取2014年1月至2022年6月接受首次干细胞动员治疗的240例淋巴瘤或MM患者为研究对象，进行回顾性单中心研究。我们评估了基线人口统计学、临床和实验室数据(粒细胞集落刺激因子和化疗实施前)的影响，包括中性粒细胞、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值、单核细胞与淋巴细胞比值、全身免疫炎症指数(SII)、全身炎症反应指数(SIRI)、中性粒细胞与c反应蛋白、中性粒细胞与ldh比值对MF的影响。结果240例患者分为动员成功214例(89.16%)和动员不良26例(10.84%)。动员不良者的中性粒细胞、NLR、SII和中性粒细胞与ldh之比较低(P值分别为0.001、0.022、0.001和0.001)。在这些标志物中，只有中性粒细胞与ldh的比值在动员性差的MM和淋巴瘤患者中都有统计学意义。采用接收算子特征曲线分析评价MF的中性粒细胞、SII和中性粒细胞/ ldh比值。中性粒细胞- ldh比值与其他两个变量相比，特异性最高(93.93%，临界值≤9.904)。多因素logistic回归分析显示，中性粒细胞/ ldh比值≤9.904(优势比为7.116,P = 0.001)、中性粒细胞计数≤3300/mm3(优势比为3.248,P = 0.021)、淋巴瘤诊断(优势比为2.674,P = 0.039)是MF的独立危险因素。结论中性粒细胞与ldh比值可作为淋巴瘤和MM患者预测首发MF的新指标。该指标的优化还需进行新的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Apheresis 医学-血液学

CiteScore

2.80

自引率

13.30%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Clinical Apheresis publishes articles dealing with all aspects of hemapheresis. Articles welcomed for review include those reporting basic research and clinical applications of therapeutic plasma exchange, therapeutic cytapheresis, therapeutic absorption, blood component collection and transfusion, donor recruitment and safety, administration of hemapheresis centers, and innovative applications of hemapheresis technology. Experimental studies, clinical trials, case reports, and concise reviews will be welcomed.