Functional and Histological Changes in Umbilical Artery and Myometrium Isolated from IUGR Complicated Pregnancies.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2023-12-01 Epub Date: 2023-08-14 DOI:10.1080/15513815.2023.2245892

Mustafa Sengul, Baris Karadas, Selin Acar-Sahan, Fatma Simsek, Ersan Horoz, Işık Cem Özok, Tijen Temiz

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引用次数: 0

Abstract

Objective: To investigate the relaxation responses mediated by L-type Ca2+ channels and big-conductance Ca²⁺-activated K⁺ (BKCa) channels and histological changes in the human umbilical artery (HUA) and myometrium smooth muscle isolated from pregnancies complicated with intrauterine growth restriction (IUGR).Methods: The muscle reactivity and the histology of the smooth muscle of the HUA and myometrium retrieved from 14 women with IUGR and 14 controls were investigated by the isolated tissue bath and immunohistochemical method.Results: In HUA, the maximum relaxation responses and pD2 values of nifedipine and NS11021 (BKCa channel opener) were significantly increased and significant histopathological changes are observed in the IUGR group.Conclusions: The pathogenesis of IUGR might be associated with the impairment in the functional responses of L-type Ca2+ channels and BKCa channels in HUA smooth muscle. The increased staining of myometrium and UC with HIF-1α in IUGR may indicate apoptosis, histological damage, and impaired fetal growth.

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IUGR并发症妊娠分离脐动脉和子宫肌层的功能和组织学改变。

目的:探讨l型Ca2+通道和大电导Ca2+活化K+ (BKCa)通道介导的舒张反应及妊娠合并宫内生长受限(IUGR)分离的人脐动脉(HUA)和子宫肌平滑肌的组织学变化。方法:采用分离组织浴法和免疫组化法，对14例IUGR妇女和14例对照组的HUA和子宫肌层进行肌肉反应性和组织学研究。结果:在HUA中，IUGR组硝苯地平和NS11021 (BKCa通道开启剂)的最大松弛反应和pD2值均显著升高，并观察到明显的组织病理改变。结论:IUGR的发病机制可能与HUA平滑肌中l型Ca2+通道和BKCa通道的功能反应受损有关。IUGR中HIF-1α对子宫肌层和UC染色增加可能提示细胞凋亡、组织学损伤和胎儿生长受损。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.