Association of lipid metabolism-related metabolites with overweight/obesity based on the FTO rs1421085†

IF 3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular omics Pub Date : 2023-08-04 DOI:10.1039/D3MO00112A

Sabiha Farooq, Sobia Rana, Amna Jabbar Siddiqui, Ayesha Iqbal, Adil Anwar Bhatti and Syed Ghulam Musharraf

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Abstract

Globally, obesity is a severe health issue. A more precise and practical approach is required to enhance clinical care and drug development. The FTO (fat mass and obesity-associated) gene variant rs1421085 is strongly associated with an increased susceptibility to obesity in numerous populations; however, the precise mechanism behind this association concerning metabolomics is still not understood. This study aims to examine the association between metabolites and obesity-related anthropometric traits based on the variant FTO rs1421085. This study was based on a case-control design involving a total of 542 participants including overweight/obese cases and healthy controls. The blood samples were collected from all the participants. The isolated serum samples were subjected to untargeted metabolomics using GC-MS. The isolated DNA samples were genotyped for the FTO rs1421085 variant. Initially, a total of 42 metabolites were identified on GC-MS, which were subjected to further association analyses. The study observed a significant association of two metabolites, glycerol and 2,3-dihydroxypropyl stearate with FTO gene variant rs1421085 and obesity-related anthropometric traits including % BF, WHtR, WC, and HC. The CT genotype of FTO rs1421085 may greatly increase the risk of overweight/obesity by changing the lipid metabolism-related metabolites. Therefore, this study highlights the significance of biochemical networks in the progression of obesity in carriers of the FTO rs1421085 risk genotype.

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基于FTO rs1421085的脂质代谢相关代谢产物与超重/肥胖的相关性。

在全球范围内，肥胖是一个严重的健康问题。需要一种更加精确和实用的方法来加强临床护理和药物开发。FTO（脂肪量和肥胖相关）基因变体rs1421085与许多人群中肥胖易感性的增加密切相关；然而，关于代谢组学，这种关联背后的确切机制仍不清楚。本研究旨在基于变异FTO rs1421085来检验代谢产物与肥胖相关的人体测量特征之间的关系。本研究基于病例对照设计，共有542名参与者参与，包括超重/肥胖病例和健康对照。从所有参与者身上采集血样。使用GC-MS对分离的血清样品进行非靶向代谢组学研究。对分离的DNA样本进行FTO rs1421085变体的基因分型。最初，在GC-MS上共鉴定了42种代谢物，并对其进行了进一步的关联分析。该研究观察到两种代谢产物甘油和2，3-二羟丙基硬脂酸酯与FTO基因变体rs1421085和肥胖相关的人体测量特征（包括%BF、WHtR、WC和HC）显著相关。FTO rs1421085的CT基因型可能通过改变脂质代谢相关代谢产物而大大增加超重/肥胖的风险。因此，本研究强调了生化网络在FTO rs1421085风险基因型携带者肥胖进展中的意义。

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来源期刊

Molecular omics Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

5.40

自引率

3.40%

发文量

期刊介绍： Molecular Omics publishes high-quality research from across the -omics sciences. Topics include, but are not limited to: -omics studies to gain mechanistic insight into biological processes – for example, determining the mode of action of a drug or the basis of a particular phenotype, such as drought tolerance -omics studies for clinical applications with validation, such as finding biomarkers for diagnostics or potential new drug targets -omics studies looking at the sub-cellular make-up of cells – for example, the subcellular localisation of certain proteins or post-translational modifications or new imaging techniques -studies presenting new methods and tools to support omics studies, including new spectroscopic/chromatographic techniques, chip-based/array technologies and new classification/data analysis techniques. New methods should be proven and demonstrate an advance in the field. Molecular Omics only accepts articles of high importance and interest that provide significant new insight into important chemical or biological problems. This could be fundamental research that significantly increases understanding or research that demonstrates clear functional benefits. Papers reporting new results that could be routinely predicted, do not show a significant improvement over known research, or are of interest only to the specialist in the area are not suitable for publication in Molecular Omics.