Intraductal papilloma with atypical ductal hyperplasia and neuroendocrine differentiation as a possible precursor lesion of solid papillary carcinoma.

IF 1.2 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2023-09-01 Epub Date: 2023-06-07 DOI:10.1007/s00795-023-00357-w

Yutaro Mihara, Rin Yamaguchi, Ryuji Takahashi, Yuta Yano, Hirohisa Yano

引用次数: 0

Abstract

Breast papillary neoplasms include a wide range of tumor types, and their pathological diagnosis is sometimes difficult. Furthermore, the etiology of these lesions is still not fully understood. We report the case of a 72-years-old woman referred to our hospital with bloody discharge from the right nipple. An imaging study detected a cystic lesion, including a solid component contiguous with the mammary duct, in the subareolar region. The lesion was then removed by segmental mastectomy. Pathological examination of the resected specimen revealed an intraductal papilloma with atypical ductal hyperplasia. Moreover, the atypical ductal epithelial cells expressed neuroendocrine markers. The presence of an intraductal papillary lesion with neuroendocrine differentiation suggests solid papillary carcinoma. Thus, this case suggests that intraductal papilloma could be a precursor of solid papillary carcinoma.

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导管内乳头状瘤伴不典型导管增生和神经内分泌分化，可能是实体乳头状癌的前兆病变。

乳腺乳头状肿瘤包括广泛的肿瘤类型，其病理诊断有时是困难的。此外，这些病变的病因尚不完全清楚。我们报告的情况下，一个72岁的妇女转介到我们的医院血性分泌物从右乳头。影像学检查发现一囊性病变，包括在乳晕下区与乳腺导管相邻的实性成分。然后通过节段性乳房切除术切除病变。切除标本的病理检查显示导管内乳头状瘤伴不典型导管增生。此外，非典型导管上皮细胞表达神经内分泌标志物。导管内乳头状病变伴神经内分泌分化提示实性乳头状癌。因此，本病例提示导管内乳头状瘤可能是实性乳头状癌的前兆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.