Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Biogerontology Pub Date : 2024-06-01 Epub Date: 2023-08-12 DOI:10.1007/s10522-023-10058-7
Xin Yin, Yiwei Meng, Chenghong Sun, Yanqiu Zhao, Weitao Wang, Peipei Zhao, Mengmeng Wang, Jingli Ren, Jingchun Yao, Lixin Zhang, Xuekui Xia
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引用次数: 0

Abstract

Jingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the pharyngeal pumping rate or nematode motility. Moreover, JFG notably increased oviposition by 11.3%. Subsequent investigations revealed that JFG enhanced oxidative stress resistance in C. elegans by reducing reactive oxygen species levels and significantly improved survival rates in nematodes infected with Pseudomonas aeruginosa ATCC 9027. These findings suggest that JFG delays reproductive senescence in C. elegans and protects them from oxidative stress, thereby extending their lifespan. Additionally, JFG improves the survival of P. aeruginosa-infected nematodes. Consequently, JFG has potential as a candidate for the development of anti-aging and anti-infection functional medicines.

Abstract Image

利用秀丽隐杆线虫模型研究京芳颗粒的抗衰老和抗感染特性
经方颗粒(JFG)是一种传统中药,临床上经常用于治疗感染性疾病。然而,JFG 的抗衰老和抗感染作用仍不确定。本研究以秀丽隐杆线虫(Caenorhabditis elegans,C. elegans)N2为模型生物,对其抗衰老和抗感染作用进行了评估。结果表明,在剂量为 10 毫克/毫升时,JFG 能显著延长秀丽隐杆线虫 31.2% 的中位寿命,且没有任何明显的不良反应,如改变咽抽速或线虫的运动能力。此外,JFG 还显著增加了 11.3% 的产卵量。随后的研究发现,JFG 通过降低活性氧水平增强了秀丽隐杆线虫的抗氧化能力,并显著提高了线虫感染铜绿假单胞菌 ATCC 9027 后的存活率。这些研究结果表明,JFG 可延缓秀丽隐杆线虫的生殖衰老,保护它们免受氧化应激,从而延长它们的寿命。此外,JFG 还能提高受绿脓杆菌感染的线虫的存活率。因此,JFG 具有开发抗衰老和抗感染功能药物的潜力。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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