Spatial composition and turnover of the main molecules in the adult glomerular basement membrane.

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
David W Smith, Azin Azadi, Chang-Joon Lee, Bruce S Gardiner
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引用次数: 2

Abstract

The glomerular basement membrane (GBM) is an important tissue structure in kidney function. It is the membrane through which filtrate and solutes must pass to reach the nephron tubules. This review focuses on the spatial location of the main extracellular matrix components of the GBM. It also attempts to explain this organization in terms of their synthesis, transport, and loss. The picture that emerges is that the collagen IV and laminin content of GBM are in a very slow dynamic disequilibrium, leading to GBM thickening with age, and in contrast, some heparan sulfate proteoglycans are in a dynamic equilibrium with a very rapid turnover (i.e. half-life measured in ~hours) and flow direction against the flow of filtrate. The highly rapid heparan sulfate turnover may serve several roles, including an unclogging mechanism for the GBM, compressive stiffness of the GBM fiber network, and/or enabling podocycte-endothelial crosstalk against the flow of filtrate.

成人肾小球基底膜中主要分子的空间组成和转换。
肾小球基底膜是影响肾功能的重要组织结构。它是滤液和溶质到达肾小管必须经过的膜。本文综述了GBM主要细胞外基质成分的空间定位。它还试图从合成、转移和损失的角度来解释这种组织。由此可见,GBM的IV型胶原和层粘连蛋白含量处于一个非常缓慢的动态不平衡状态,导致GBM随着年龄的增长而变厚,而硫酸肝素蛋白多糖则处于一个动态不平衡状态,其周转非常快(即半衰期以~h计),流动方向与滤液的流动方向相反。硫酸肝素的快速周转可能有多种作用,包括GBM的疏通机制,GBM纤维网络的压缩刚度,和/或使足细胞-内皮细胞串扰对抗滤液的流动。
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来源期刊
Tissue Barriers
Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.60
自引率
6.50%
发文量
25
期刊介绍: Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.
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