Can lipid mediators and free fatty acids guide acute coronary syndrome diagnosis and treatment?

Laboratory medicine Pub Date : 2024-01-06 DOI:10.1093/labmed/lmad042

Gulbahar Uzun, Aslihan Unal, Ibrahim Basarici, Murathan Kucuk, Levent Donmez, Cahit Nacitarhan, Sebahat Özdem

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Abstract

Objective: The aim of this study was to investigate fatty acids, lipid mediator levels, and the desaturase index rates on different acute coronary syndrome types and their possible relationship with routine lipid parameters.

Methods: The study included 81 patients with myocardial infarction (MI), 20 patients with unstable angina pectoris, and 31 healthy people. Fatty acids, CD59, lipoxin A4, 8-isoprostane, serum lipids, albumin, C-reactive protein (CRP), and high sensitive troponin levels were measured in all participants.

Results: When the fatty acid groups were evaluated as a ratio of albumin, MUFA/albumin and SFA/albumin ratios were significantly higher in the MI group compared to the control group. Although CD59 and lipoxin A4 levels were higher in the control group, there was no significant differences between the groups. When lipoxin A4/CRP and CD59/CRP ratios were evaluated, the results were significantly lower than those in the control group.

Conclusion: Lipid mediators may be useful in treating atherosclerosis by contributing to the resolution of inflammation.

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脂质介质和游离脂肪酸能否指导急性冠脉综合征的诊断和治疗？

研究目的本研究旨在调查不同急性冠状动脉综合征类型的脂肪酸、脂质介质水平和去饱和酶指数率及其与常规血脂参数的可能关系：研究对象包括 81 名心肌梗死（MI）患者、20 名不稳定型心绞痛患者和 31 名健康人。对所有参与者的脂肪酸、CD59、脂毒素 A4、8-异前列腺素、血清脂质、白蛋白、C反应蛋白（CRP）和高敏肌钙蛋白水平进行了测量：以白蛋白比率评估脂肪酸组时，与对照组相比，心肌梗死组的 MUFA/ 白蛋白比率和 SFA/ 白蛋白比率明显较高。虽然对照组的 CD59 和脂毒素 A4 水平较高，但两组间无明显差异。在评估脂质毒素 A4/CRP 和 CD59/CRP 比率时，结果明显低于对照组：结论：脂质介质可促进炎症的消退，从而有助于治疗动脉粥样硬化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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