Electrophysiological trajectories of concussion recovery: From acute to prolonged stages in late teenagers.

IF 0.8 Q4 PEDIATRICS
Mo Mortazavi, Francesca Arese Lucini, David Joffe, David S Oakley
{"title":"Electrophysiological trajectories of concussion recovery: From acute to prolonged stages in late teenagers.","authors":"Mo Mortazavi, Francesca Arese Lucini, David Joffe, David S Oakley","doi":"10.3233/PRM-210114","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Numerous studies have reported electrophysiological differences between concussed and non-concussed groups, but few studies have systematically explored recovery trajectories from acute concussion to symptom recovery and the transition from acute concussion to prolonged phases. Questions remain about recovery prognosis and the extent to which symptom resolution coincides with injury resolution. This study therefore investigated the electrophysiological differences in recoveries between simple and complex concussion.</p><p><strong>Methods: </strong>Student athletes with acute concussion from a previous study (19(2) years old) were tracked from pre-injury baseline, 24-48 hours after concussion, and through in-season recovery. The electroencephalography (EEG) with P300 evoked response trajectories from this acute study were compared to an age-matched population of 71 patients (18(2) years old) with prolonged post-concussive symptoms (PPCS), 61 (SD 31) days after concussion.</p><p><strong>Results: </strong>Acute, return-to-play, and PPCS groups all experienced a significant deficit in P300 amplitude compared to the pre-injury baseline group. The PPCS group, however, had significantly different EEG spectral and coherence patterns from every other group.</p><p><strong>Conclusion: </strong>These data suggest that while the evoked response potentials deficits of simple concussion may persist in more prolonged stages, there are certain EEG measures unique to PPCS. These metrics are readily accessible to clinicians and may provide useful parameters to help predict trajectories, characterize injury (phenotype), and track the course of injury.</p>","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":"16 2","pages":"287-299"},"PeriodicalIF":0.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10894572/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pediatric rehabilitation medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/PRM-210114","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: Numerous studies have reported electrophysiological differences between concussed and non-concussed groups, but few studies have systematically explored recovery trajectories from acute concussion to symptom recovery and the transition from acute concussion to prolonged phases. Questions remain about recovery prognosis and the extent to which symptom resolution coincides with injury resolution. This study therefore investigated the electrophysiological differences in recoveries between simple and complex concussion.

Methods: Student athletes with acute concussion from a previous study (19(2) years old) were tracked from pre-injury baseline, 24-48 hours after concussion, and through in-season recovery. The electroencephalography (EEG) with P300 evoked response trajectories from this acute study were compared to an age-matched population of 71 patients (18(2) years old) with prolonged post-concussive symptoms (PPCS), 61 (SD 31) days after concussion.

Results: Acute, return-to-play, and PPCS groups all experienced a significant deficit in P300 amplitude compared to the pre-injury baseline group. The PPCS group, however, had significantly different EEG spectral and coherence patterns from every other group.

Conclusion: These data suggest that while the evoked response potentials deficits of simple concussion may persist in more prolonged stages, there are certain EEG measures unique to PPCS. These metrics are readily accessible to clinicians and may provide useful parameters to help predict trajectories, characterize injury (phenotype), and track the course of injury.

脑震荡恢复的电生理轨迹:从急性期到晚期青少年的长期阶段。
目的:许多研究报告了脑震荡组和非脑震荡组之间的电生理差异,但很少有研究系统地探讨了从急性脑震荡到症状恢复以及从急性脑震荡过渡到长期阶段的恢复轨迹。有关恢复预后以及症状缓解与损伤缓解的吻合程度的问题依然存在。因此,本研究调查了简单脑震荡和复杂脑震荡恢复期的电生理差异:方法:对先前研究中患有急性脑震荡的学生运动员(19(2)岁)进行了从受伤前基线、脑震荡后 24-48 小时到赛季中恢复期的跟踪调查。将这项急性研究中的脑电图(EEG)和 P300 诱发反应轨迹与脑震荡后 61 天(标准偏差 31 天)、年龄匹配的 71 名脑震荡后症状(PPCS)延长期患者(18(2)岁)进行了比较:与受伤前基线组相比,急性期组、重返赛场组和 PPCS 组的 P300 波幅都出现了明显的缺陷。然而,PPCS 组的脑电图频谱和相干模式与其他各组均有显著不同:这些数据表明,虽然单纯脑震荡的诱发反应电位缺陷可能会持续较长时间,但 PPCS 有某些独特的脑电图测量指标。临床医生很容易获得这些指标,它们可提供有用的参数,帮助预测轨迹、描述损伤特征(表型)和跟踪损伤过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.30
自引率
5.30%
发文量
139
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信