Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females: Implication of menopause and ageing

IF 3

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2023-08-01 DOI:10.1016/j.plefa.2023.102581

Sara Sousa , Diogo Pestana , Gil Faria , Cristina Delerue-Matos , Conceição Calhau , Valentina Fernandes Domingues

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Abstract

Fatty acids (FA) are biomarkers of metabolic dysfunction. Adipose tissue is the largest reservoir of FA and acts differently in obese individuals. Menopause by itself significantly alters metabolism, lipid metabolism dysregulation, and adipose tissue distribution. How adipose tissue FA alters an obese individual's metabolism depending on a female's menopausal status is yet poorly understood.

Hence, the subcutaneous (scAT) and visceral adipose tissue (vAT) FA profile for 173 obese premenopausal and postmenopausal women was measured and associated with biochemical parameters. scAT and vAT FA profiles were distinct by themselves and in menopause. In total 816 associations were found with biochemical parameters, where only 58 were independent of the menopausal status.

The associations found to emphasize the importance of assessing the adipose tissue FA profile and how their behavior changes with menopause. The FA are crucial in metabolic processes and can be helpful biomarkers in the prevention/treatment and follow-up of female obesity.

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脂肪组织脂肪酸作为肥胖女性代谢功能障碍的生物标志物:绝经和衰老的含义

脂肪酸（FA）是代谢功能障碍的生物标志物。脂肪组织是FA最大的储存库，在肥胖个体中的作用不同。更年期本身会显著改变新陈代谢、脂质代谢失调和脂肪组织分布。脂肪组织FA如何根据女性更年期状态改变肥胖者的新陈代谢，目前尚不清楚。因此，对173名绝经前和绝经后肥胖妇女的皮下（scAT）和内脏脂肪组织（vAT）FA图谱进行了测量，并与生化参数相关。scAT和vAT-FA的特征在自身和更年期是不同的。总共发现816个与生化参数相关，其中只有58个与更年期状态无关。研究发现，这些关联强调了评估脂肪组织FA特征的重要性，以及它们的行为如何随着更年期而变化。FA在代谢过程中至关重要，在女性肥胖的预防/治疗和随访中可以成为有用的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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