Evaluation of acute toxicity and antiulcer activity of Pepgard tablet: An Ayurvedic formulation.

Ayu Pub Date : 2022-01-01 Epub Date: 2023-06-24 DOI:10.4103/ayu.ayu_384_21
Khushbu Bakulbhai Joshi, Falguni Saraswat, Mukeshkumar B Nariya
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Abstract

Background: In traditional Indian medicine, several plants have been used to treat gastrointestinal disorders, including gastric ulcers. Pepgard tablet is an Ayurvedic compound formulation widely used in clinical practice as an antacid for treating nonulcer dyspepsia, gastroesophageal reflux, and drug-induced gastritis.

Aim: Evaluation of acute toxicity of Pepgard tablet and antiulcer activity against gastric ulcer induced by aspirin plus pyloric ligation in albino rats.

Materials and methods: Acute toxicity was studied as per OECD 425 guideline at a limit dose of 2000 mg/kg in female albino rats. Antiulcer activity was assessed by aspirin plus pyloric ligation model at two dose levels (90 and 180 mg/kg, po). Gastric juice parameters, stomach tissue parameters, and histopathological study along with an assessment of ulcer index were assessed.

Results: Pepgard did not produce any toxicity or lethality at a limit dose of 2000 mg/kg and was found safe in female albino rats. Pepgard at both dose levels showed an antiulcer effect as evidenced by an increase in pH value, decreased acidity, and peptic activity of gastric juice along with a decrease in ulcer index and increased antioxidant status of damaged gastric mucosa as revealed by an increase in catalase, glutathione, etc., in stomach homogenate of albino rats.

Conclusion: The present study of Pepgard tablet revealed its safety in acute toxicity studies and can be categorized as substances with low health hazard potential. Pepgard has been shown to be effective as an antacid, anti-ulcer, and to have gastroprotective effects against experimentally-induced ulcerogenesis in albino rats.

Pepgard片剂的急性毒性和抗溃疡活性评估:阿育吠陀制剂。
背景:在印度传统医学中,几种植物已被用于治疗胃肠道疾病,包括胃溃疡。Pepgard片剂是一种阿育吠陀复方制剂,在临床实践中广泛用作抗酸剂,用于治疗非溃疡性消化不良、胃食管反流和药物性胃炎。目的:评价Pepgard片对阿司匹林加幽门结扎大鼠胃溃疡的急性毒性和抗溃疡活性。材料和方法:根据OECD 425指南,在2000 mg/kg的限量剂量下,对雌性白化大鼠进行急性毒性研究。通过阿司匹林加幽门结扎模型在两个剂量水平(90和180 mg/kg,po)下评估抗溃疡活性。评估胃液参数、胃组织参数、组织病理学研究以及溃疡指数评估。结果:在2000 mg/kg的限量剂量下,Pepgard不会产生任何毒性或致死性,并且在雌性白化大鼠中是安全的。两种剂量水平的Pepgard均表现出抗溃疡作用,表现为胃液的pH值升高、酸度降低和消化活性降低,溃疡指数降低,受损胃粘膜的抗氧化状态增强,表现为白化大鼠胃匀浆中过氧化氢酶、谷胱甘肽等的增加。结论:本研究表明,Pepgard片在急性毒性研究中是安全的,可归类为低健康危害物质。Pepgard已被证明是一种有效的抗酸剂、抗溃疡剂,并对实验诱导的白化大鼠溃疡发生具有胃保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Ayu
Ayu
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