Epidemiologic Characteristics, Time Trend, and Seasonality of Orofacial Clefts in São Paulo State, Brazil. 2008-2019.

IF 1.2 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Cleft Palate-Craniofacial Journal Pub Date : 2024-11-01 Epub Date: 2023-06-08 DOI:10.1177/10556656231181007

Mauricio Giusti Calderon, Victoria Caleffi Oliveira Simoni, Brunna Gonçalves de Souza Ferreira, Adonis Florença de Moraes, Mariana Araújo Gomes, Vivian Sumie Hatakeyama, Edige Felipe de Sousa Santos

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引用次数: 0

Abstract

Objective: To characterize the epidemiology, identify trends in prevalence, seasonality, and risk factors for orofacial clefts (OFC), selecting the São Paulo state (SPS) population database.

Design: A population-based study to estimate the OFC prevalence trends in recent years, stratified by maternal age and SPS geographical clusters.

Setting: All live births (LB) with OFC in SPS from 2008-2019.

Patients: 5342 cases of OFC among 7 301 636 LB.

Interventions: Not applicable.

Main outcome measures: OFC prevalence trends, annual percent change (APC) with a 95% confidence interval, and seasonality.

Results: We found an OFC prevalence of 7.3/10 000LB in SPS, Brazil. Among all the cases, the majority were male (57.1%), Caucasian (65.4%), 77.8% born at term, 75.8% weight >2500 g, 97.1% singleton, and 63.9% of births were by cesarean section. From 2008-2019, SPS presented a stationary OFC prevalence trend; in São Paulo city, the highest APC was observed (0.05%); the maternal age group with the highest OFC prevalence rate was ≥35 years (9.2/10 000LB). We identified the existence of seasonal variation based on the conception date in the final months of the year, corresponding to the spring season (P < .001).

Conclusion: OFC had a stationary prevalence trend in recent years, with the highest prevalence in the Central North Cluster and ≥35 years maternal age group. Seasonality was observed in the spring season, and congenital malformation of lips was the most common associated pathology. This population-based study is the first to summarize the current epidemiology of OFC in SPS.

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巴西圣保罗州口面裂的流行病学特征、时间趋势和季节性。2008-2019.

目的选择圣保罗州（SPS）人口数据库，描述口面裂（OFC）的流行病学特征，确定流行趋势、季节性和风险因素：设计：一项基于人口的研究，根据产妇年龄和圣保罗州的地理集群分层，估计近年来口面裂的流行趋势：研究对象：2008-2019年间圣保罗州所有患有OFC的活产婴儿（LB）：干预措施：不适用：干预措施：不适用：主要结果测量指标：OFC患病率趋势、年百分比变化（APC）（95%置信区间）和季节性：结果：我们发现，OFC 在巴西 SPS 的流行率为 7.3/10 000LB。在所有病例中，大多数为男性（57.1%）、白种人（65.4%）、77.8%为足月产、75.8%体重大于2500克、97.1%为单胎、63.9%为剖宫产。从2008年至2019年，SPS呈现出固定的OFC流行趋势；在圣保罗市观察到最高的APC（0.05%）；OFC流行率最高的产妇年龄组为≥35岁（9.2/10 000LB）。我们根据一年中最后几个月的受孕日期（与春季相对应）发现存在季节性变化（P 结论）：近年来，卵巢功能衰竭的发病率呈稳定趋势，中北部群组和≥35 岁产妇年龄组的发病率最高。春季是发病的季节性，先天性口唇畸形是最常见的相关病症。这项以人群为基础的研究首次总结了目前萨斯喀彻温省口腔扁桃体炎的流行病学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cleft Palate-Craniofacial Journal 医学-外科

CiteScore

2.70

自引率

36.40%

发文量

215

期刊介绍： The Cleft Palate-Craniofacial Journal (CPCJ) is the premiere peer-reviewed, interdisciplinary, international journal dedicated to current research on etiology, prevention, diagnosis, and treatment in all areas pertaining to craniofacial anomalies. CPCJ reports on basic science and clinical research aimed at better elucidating the pathogenesis, pathology, and optimal methods of treatment of cleft and craniofacial anomalies. The journal strives to foster communication and cooperation among professionals from all specialties.