MicroRNAs in cancer metastasis: biological and therapeutic implications.

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Marie Sell, Charmaine A Ramlogan-Steel, Jason C Steel, Bijay P Dhungel
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引用次数: 3

Abstract

Cancer metastasis is the primary cause of cancer-related deaths. The seeding of primary tumours at a secondary site is a highly inefficient process requiring substantial alterations in the genetic architecture of cancer cells. These alterations include significant changes in global gene expression patterns. MicroRNAs are small, non-protein coding RNAs which play a central role in regulating gene expression. Here, we focus on microRNA determinants of cancer metastasis and examine microRNA dysregulation in metastatic cancer cells. We dissect the metastatic process in a step-wise manner and summarise the involvement of microRNAs at each step. We also discuss the advantages and limitations of different microRNA-based strategies that have been used to target metastasis in pre-clinical models. Finally, we highlight current clinical trials that use microRNA-based therapies to target advanced or metastatic tumours.

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microrna在癌症转移中的生物学和治疗意义。
癌症转移是癌症相关死亡的主要原因。在继发部位播种原发肿瘤是一个非常低效的过程,需要对癌细胞的遗传结构进行实质性的改变。这些改变包括全球基因表达模式的显著变化。MicroRNAs是一种小的非蛋白质编码rna,在调节基因表达中起着核心作用。在这里,我们专注于癌症转移的microRNA决定因素,并研究转移性癌细胞中的microRNA失调。我们以循序渐进的方式剖析了转移过程,并总结了microrna在每个步骤中的作用。我们还讨论了在临床前模型中用于靶向转移的不同基于microrna的策略的优点和局限性。最后,我们重点介绍了目前使用基于microrna的疗法靶向晚期或转移性肿瘤的临床试验。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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