Dichotomous role of autophagy in cancer.

IF 0.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Asian Biomedicine Pub Date : 2022-06-30 eCollection Date: 2022-06-01 DOI:10.2478/abm-2022-0014

Amin Arif, Muhammad Babar Khawar, Rabia Mehmood, Muddasir Hassan Abbasi, Nadeem Sheikh

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Abstract

Autophagy is an evolutionary conserved catabolic process that plays physiological and pathological roles in a cell. Its effect on cellular metabolism, the proteome, and the number and quality of organelles, diversely holds the potential to alter cellular functions. It acts paradoxically in cancer as a tumor inhibitor as well as a tumor promoter. In the early stage of tumorigenesis, it prevents tumor initiation by the so-called "quality control mechanism" and suppresses cancer progression. For late-staged tumors that are exposed to stress, it acts as a vibrant process of degradation and recycling that promotes cancer by facilitating metastasis. Despite this dichotomy, the crucial role of autophagy is evident in cancer, and associated with mammalian targets of rapamycin (mTOR), p53, and Ras-derived major cancer networks. Irrespective of the controversy regarding autophagic manipulation, promotion and suppression of autophagy act as potential therapeutic targets in cancer treatment and may provide various anticancer therapies.

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自噬在癌症中的双重作用

自噬是一种进化保守的分解代谢过程，在细胞中发挥着生理和病理作用。它对细胞新陈代谢、蛋白质组以及细胞器的数量和质量都有影响，有可能改变细胞功能。在癌症中，它既是肿瘤的抑制剂，也是肿瘤的促进剂。在肿瘤发生的早期阶段，它通过所谓的 "质量控制机制 "阻止肿瘤的发生，并抑制肿瘤的发展。而对于处于应激状态的晚期肿瘤来说，它则是一个充满活力的降解和循环过程，通过促进转移来促进癌症的发生。尽管存在这种对立，但自噬在癌症中的关键作用显而易见，并且与雷帕霉素哺乳动物靶标（mTOR）、p53 和 Ras 衍生的主要癌症网络有关。无论自噬操作存在何种争议，促进和抑制自噬都是癌症治疗中的潜在治疗靶点，可提供多种抗癌疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Biomedicine 医学-医学：研究与实验

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.