Ultrasonographic shear wave elastography of the thyroid in patients with sickle cell anemia.

IF 0.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Asian Biomedicine Pub Date : 2022-06-01 DOI:10.2478/abm-2022-0017

Gulen Burakgazi, Gul Ilhan, Oguzhan Ozcan, Emre Dirican

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引用次数: 0

Abstract

Background: Although thyroid radiology has been conducted in patients with sickle cell anemia (SCA), to our knowledge, there is no report of thyroid gland assessment using ultrasonographic shear wave elastography (US-SWE).

Objectives: To determine values for ultrasonographic US-SWE of the thyroid in patients with SCA and correlations between thyroid elasticity and biochemical variables used to evaluate thyroid function.

Methods: Prospective case-control observational study of 36 patients with SCA and 33 healthy volunteer controls. US-SWE measurements of thyroid gland parenchyma and biochemical parameters of the participants were obtained and compared, and the diagnostic accuracy of elasticity was determined.

Results: The thyroid volume was smaller in patients with SCA than that in controls (P = 0.001). Compared with the controls, the patients with SCA had significantly lower serum levels of free triiodothyronine (fT3) (P = 0.004) and thyroglobulin (Tg) (P = 0.001) and significantly higher levels of thyroid-stimulating hormone (P = 0.028). Thyroid stiffness was significantly higher in the left lobe (LL) of the patients with SCA than in the controls (P = 0.003). In the patients with SCA, we found a significant correlation between right lobe (RL) and LL stiffness and serum levels of Tg (RL [r = -0.439] and LL [r = -0.484]; P = 0.021) and fT3 (RL [r = -0.463] and LL [r = -0.386]; P = 0.012). Receiver operating characteristic (ROC) curve analysis of thyroid elasticity that represented a diagnosis of SCA found a cutoff of >7.31 kPa, a sensitivity of 52.0%, and a specificity of 72.0% for the RL (P = 0.316, area under the curve [AUC] 0.570), and a cutoff of >8.06 kPa, a sensitivity of 58.0%, and a specificity of 84.0% for the LL (P = 0.011, AUC 0.680).

Conclusions: US-SWE can be used to follow up thyroid changes in patients with SCA.

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镰状细胞性贫血患者甲状腺的超声剪切波弹性成像。

背景:虽然镰状细胞性贫血(SCA)患者已经进行了甲状腺放射学检查，但据我们所知，尚未有使用超声剪切波弹性成像(US-SWE)评估甲状腺的报道。目的:探讨SCA患者甲状腺超声US-SWE值及甲状腺弹性与甲状腺功能生化指标的相关性。方法:对36例SCA患者和33名健康志愿者进行前瞻性病例对照观察研究。获得了参与者甲状腺实质和生化参数的US-SWE测量值并进行了比较，确定了弹性的诊断准确性。结果:SCA患者甲状腺体积小于对照组(P = 0.001)。与对照组相比，SCA患者血清游离三碘甲状腺原氨酸(fT3)水平(P = 0.004)和甲状腺球蛋白(Tg)水平(P = 0.001)显著降低，促甲状腺激素水平显著升高(P = 0.028)。SCA患者左叶(LL)甲状腺僵硬度明显高于对照组(P = 0.003)。在SCA患者中，我们发现右叶(RL)和左叶僵硬度与血清Tg水平有显著相关性(RL [r = -0.439]和LL [r = -0.484];P = 0.021)和fT3 (RL [r = -0.463]和LL [r = -0.386];P = 0.012)。诊断SCA的甲状腺弹性的受试者工作特征(ROC)曲线分析发现，RL的截断值>7.31 kPa，灵敏度为52.0%，特异性为72.0% (P = 0.316，曲线下面积[AUC] 0.570); LL的截断值>8.06 kPa，灵敏度为58.0%，特异性为84.0% (P = 0.011, AUC 0.680)。结论:US-SWE可用于SCA患者甲状腺变化的随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Biomedicine 医学-医学：研究与实验

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.