Usefulness of SPISE Index for Screening and Detection of Early Stages of Insulin Resistance among Chilean Young Adults.

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Annals of Nutrition and Metabolism Pub Date : 2023-01-01 Epub Date: 2023-08-08 DOI:10.1159/000533222

Isabel Pereyra González, Sandra Lopez-Arana

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引用次数: 0

Abstract

Background: As the gold standard test to quantify insulin resistance (IR) involves intravenous insulin loading and repeated blood glucose monitoring, many indexes have been developed for IR assessment for convenience.

Objective: The objective of this study was to evaluate the agreement of the Single-Point Insulin Sensitivity Estimator (SPISE) by comparing it with the homeostasis model assessment of insulin resistance (HOMA-IR) in identifying IR.

Method: Data came from the ongoing LIMACHE BIRTH COHORT. 1,948 individuals (aged 22-28 years) were studied. We performed an agreement plot called a Bangdiwala's Observer Agreement to evaluate patterns in departures from agreement in ordinal categorical variables.

Results: According to the Bangdiwala-Weighted statistics, we found that the agreement between both indexes was 0.14; this value would be considered a slight agreement. Thus, we found bias in the marginal distributions, and we noticed that the SPISE has a bias toward the central quintiles of the index.

Conclusions: The identification of IR in young adult individuals by the SPISE index has slight agreement with HOMA-IR. Therefore, caution would be taken when considering SPISE index among young Chilean adults.

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SPISE指数在智利年轻人早期胰岛素抵抗筛查和检测中的作用。

背景：由于量化胰岛素抵抗（IR）的金标准测试涉及静脉注射胰岛素负荷和重复血糖监测，为了方便起见，已经开发了许多指标来评估IR。目的：本研究的目的是通过将单点胰岛素敏感性估计器（SPISE）与胰岛素抵抗稳态模型评估（HOMA-IR）进行比较来评估其在识别IR方面的一致性。方法：数据来自正在进行的LIMACHE BIRTH COHORT。对1948名个体（年龄22-28岁）进行了研究。我们执行了一个称为Bangdiwala观察者协议的协议图，以评估有序分类变量中偏离协议的模式。结果：根据Bangdiwala加权统计，两个指标的一致性为0.14；这个值将被认为是一个轻微的一致性。因此，我们在边际分布中发现了偏差，我们注意到SPISE对指数的中心五分位数有偏差。结论：SPISE指数在青年个体中的IR鉴定与HOMA-IR略有一致。因此，在考虑智利年轻成年人的SPISE指数时应谨慎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Nutrition and Metabolism 医学-内分泌学与代谢

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.