Relationship between blood monocyte-HDL ratio and carotid intima media thickness in with postmenopausal women

IF 1.7 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Ender Erden , Ayla Cagliyan Turk , Nurdan Fidan , Ebru Erden
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引用次数: 0

Abstract

Introduction/Background: The monocyte-to-high-density lipoprotein (HDL) ratio (MHR) and carotid intima media thickness may be used as a marker of inflammation and oxidative stres. This study is aimed to investigate the role of MHR in etiopathogenesis and to determine the association between MHR and carotid intima media thickness, fracture risk, and quality of life (QoL) in postmenopausal osteoporosis patients without comorbidities. Methodology: Sixty osteoporosis, sixty osteopenia and sixty control groups were included in the prospective study evaluating postmenapausal women. The monocyte, HDL, and MHR values of all patients were evaluated. The bone mineral density of the participants was determined using the dual energy X-ray absorptiometry device. The fracture risk was assessed using the Turkish model of the Fracture Risk Assessment Tool. The QoL was determined using the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) scale, and carotid intima media thickness ultrasonography was used. Results: The age, body mass index, duration of menopause, monocyte, HDL, and MHR were similar in all three groups. carotid intima media thickness was higher in the osteoporosis group than in the normal group (p=0.015). A positive correlation was found between L1-4 total T score and monocytes, major osteoporotic fracture risk and physical function from QUALEFFO-41 sub-headings, MHR and QUALEFFO-41 total score (p<0.05). When all participants were evaluated, a positive correlation was found between femoral neck T score and MHR, L1-4 total T score and monocytes, while a negative correlation was found between L1-4 total T score and CIMT (p<0.05). Conclusion: Among postmenopausal women without comorbidities, MHR in the osteoporosis group was similar to that of the osteopenia and normal groups. Monocyte and MHR correlate with femoral neck T score and L1-4 total T score. CIMT was associated with a decreased L1–4 total T-score and an increased fracture risk, but not with MHR.

绝经后妇女颈动脉中内膜厚度与血单核细胞-高密度脂蛋白比值的关系
引言/背景:单核细胞与高密度脂蛋白(HDL)的比值(MHR)和颈动脉内膜中膜厚度可作为炎症和氧化应激的标志。本研究旨在研究MHR在发病机制中的作用,并确定无合并症的绝经后骨质疏松症患者的MHR与颈动脉内膜-中膜厚度、骨折风险和生活质量(QoL)之间的关系。方法:将60个骨质疏松症组、60个骨质减少组和60个对照组纳入评估绝经后妇女的前瞻性研究。评估所有患者的单核细胞、高密度脂蛋白和MHR值。使用双能X射线吸收仪测定参与者的骨密度。使用骨折风险评估工具的土耳其模型评估骨折风险。使用欧洲骨质疏松基金会的生活质量问卷(QUALEFFO-41)量表测定生活质量,并使用颈动脉内膜-中膜厚度超声检查。结果:三组患者的年龄、体重指数、绝经时间、单核细胞、高密度脂蛋白和MHR均相似。骨质疏松组的颈动脉内膜-中膜厚度高于正常组(p=0.015)。从QUALEFFO-41子标题、MHR和QUALEFFO-41总分来看,L1-4总T评分与单核细胞、主要骨质疏松性骨折风险和身体功能呈正相关(p<0.05)。当评估所有参与者时,股骨颈T评分与MHR呈正相关,L1-4总T评分与单核细胞呈正相关,而L1-4总T评分与CIMT呈负相关(p<0.05)。单核细胞和MHR与股骨颈T评分和L1-4总T评分相关。CIMT与L1-4总T评分降低和骨折风险增加有关,但与MHR无关。
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来源期刊
Journal of Clinical Densitometry
Journal of Clinical Densitometry 医学-内分泌学与代谢
CiteScore
4.90
自引率
8.00%
发文量
92
审稿时长
90 days
期刊介绍: The Journal is committed to serving ISCD''s mission - the education of heterogenous physician specialties and technologists who are involved in the clinical assessment of skeletal health. The focus of JCD is bone mass measurement, including epidemiology of bone mass, how drugs and diseases alter bone mass, new techniques and quality assurance in bone mass imaging technologies, and bone mass health/economics. Combining high quality research and review articles with sound, practice-oriented advice, JCD meets the diverse diagnostic and management needs of radiologists, endocrinologists, nephrologists, rheumatologists, gynecologists, family physicians, internists, and technologists whose patients require diagnostic clinical densitometry for therapeutic management.
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