Health state utilities associated with hyperphagia: Data for use in cost-utility models.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Obesity Science & Practice Pub Date : 2023-02-01 eCollection Date: 2023-08-01 DOI:10.1002/osp4.652
Timothy A Howell, Louis S Matza, Usha G Mallya, Anthony P Goldstone, W Scott Butsch, Ethan Lazarus
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Abstract

Objective: Rare genetic diseases of obesity typically present with hyperphagia, a pathologic desire to consume food. Cost-utility models assessing the value of treatments for these rare diseases will require health state utilities representing hyperphagia. This study estimated utilities associated with various hyperphagia severity levels.

Methods: Four health state vignettes were developed using published literature and clinician input to represent various severity levels of hyperphagia. Utilities were estimated for these health states in a time trade-off elicitation study in a UK general population sample.

Results: In total, 215 participants completed interviews (39.5% male; mean age 39.1 years). Mean (SD) utilities were 0.98 (0.02) for no hyperphagia, 0.91 (0.10) for mild hyperphagia, 0.70 (0.30) for moderate hyperphagia, and 0.22 (0.59) for severe hyperphagia. Mean (SD) disutilities were -0.08 (0.10) for mild, -0.28 (0.30) for moderate, and -0.77 (0.58) for severe hyperphagia.

Conclusions: These data show increasing severity of hyperphagia is associated with decreased utility. Utilities associated with severe hyperphagia are similar to those of other health conditions severely impacting quality of life (QoL). These findings highlight that treatments addressing substantial QoL impacts of severe hyperphagia are needed. Utilities estimated here may be useful in cost-utility models of treatments for rare genetic diseases of obesity.

Abstract Image

与多食相关的健康状态效用:用于成本效用模型的数据。
目的:罕见的遗传性肥胖症通常表现为食欲亢进,这是一种病态的进食欲望。评估这些罕见疾病治疗价值的成本效用模型需要代表多食症的健康状态效用。本研究估算了与各种多食症严重程度相关的效用:方法:利用已发表的文献和临床医生的意见,开发了四种健康状态案例,以代表不同严重程度的吞咽过度。结果:共有 215 名参与者完成了访谈:共有 215 名参与者完成了访谈(39.5% 为男性;平均年龄为 39.1 岁)。无多食的平均(标清)效用为 0.98 (0.02),轻度多食为 0.91 (0.10),中度多食为 0.70 (0.30),重度多食为 0.22 (0.59)。轻度、中度和重度吞咽过多症的平均(标清)损耗分别为-0.08(0.10)、-0.28(0.30)和-0.77(0.58):这些数据表明,多食症严重程度的增加与效用的降低有关。与严重多食症相关的效用与其他严重影响生活质量(QoL)的健康状况相似。这些研究结果突出表明,需要针对严重多食症对生活质量的重大影响采取治疗措施。此处估算的效用可能有助于建立治疗罕见遗传性肥胖症的成本效用模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Obesity Science & Practice
Obesity Science & Practice ENDOCRINOLOGY & METABOLISM-
CiteScore
4.20
自引率
4.50%
发文量
73
审稿时长
29 weeks
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