Pyroptosis in neurodegenerative diseases: What lies beneath the tip of the iceberg?

IF 4.3 4区 医学 Q2 IMMUNOLOGY
Mengli Yue, Li Xiao, Rui Yan, Xinyi Li, Wei Yang
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引用次数: 2

Abstract

Neurodegenerative diseases gradually receive attention with a rapidly aging global population. The hallmark of them is a progressive neuronal loss in the brain or peripheral nervous system due to complex reasons ranging from protein aggregation, immune dysregulation to abnormal cell death. The death style of nerve cell is no longer restricted to apoptosis, autophagy and necrosis as confirmed before. With the successive discoveries of the gasdermin (GSDM) protein family and key caspase molecules in the past several decades, pyroptosis emerges as a novel kind of programmed cell death. A substantial body of evidence has recognized the close connection between pyroptosis and the occurrence and development of neurodegenerative diseases. In this review, we summarize molecular mechanisms of pyroptosis, evidences for pyroptosis involvement in neurodegenerative diseases and finally we hope to provide a novel angle for clinical decision-making.

神经退行性疾病中的焦亡:冰山一角下隐藏着什么?
随着全球人口的迅速老龄化,神经退行性疾病逐渐受到人们的关注。它们的特征是由于复杂的原因,从蛋白质聚集、免疫失调到异常细胞死亡,在大脑或周围神经系统中发生进行性神经元损失。神经细胞的死亡方式不再局限于之前所确认的凋亡、自噬和坏死。在过去的几十年里,随着gasdermin (GSDM)蛋白家族和关键的caspase分子的不断发现,焦亡作为一种新的程序性细胞死亡出现。大量证据已经认识到焦亡与神经退行性疾病的发生和发展之间的密切联系。本文就焦亡的分子机制、焦亡参与神经退行性疾病的证据进行综述,以期为临床决策提供一个新的角度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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