Atomoxetine and escitalopram migrate the derangement of the temporomandibular joint morphologic and histologic changes in rats exposed to stress-induced depression.

IF 1.9 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Journal of oral science Pub Date : 2023-10-01 Epub Date: 2023-07-31 DOI:10.2334/josnusd.23-0077
Thanatta Songphaeng, Sarawut Lapmanee, Sakkarin Bhubhanil, Kamonchanok Momdee, Catleya Rojviriya, Kemporn Kitsahawong, Pattama Chailertvanitkul, Jariya U Welbat, Supawich Morkmued
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引用次数: 0

Abstract

Purpose: The purpose of this in vivo study was to determine the effects of stress-induced depression and antidepressants on depressive-like behavior, microstructure, and histomorphology of the temporomandibular joint (TMJ) using rats.

Methods: Experimentally induced depression in rats was created before being treated with two antidepressants; escitalopram (selective-serotonin-reuptake inhibitors) and atomoxetine (norepinephrine-reuptake inhibitors). Micro-computed tomography (Micro-CT) was performed to measure the change in bone volume and bone porosity of the condyle. Further histological evaluation of the condylar cartilage was performed.

Results: Micro-CT scanning revealed a decrease in bone volume in the depression group. The bone porosity percentage significantly increased in both the escitalopram and atomoxetine groups compared with the control group and the depression group. Histopathological analysis showed increased thickness of cartilage layers in the depression group. In the atomoxetine group, there was a significant increase in the pre-hypertrophic and hypertrophic layer thickness and cell count, but a significant decrease in proteoglycans.

Conclusion: The present study findings indicated the change in TMJ characteristics, especially on the superficial part of the condylar head in the depression group. Concerning the applicability of the different antidepressants, depression with the treatment of atomoxetine has the most disadvantages due to bone porosity and cartilaginous condyle changes.

阿托莫西汀和艾司西酞普兰迁移暴露于应激诱导的抑郁症大鼠颞下颌关节形态和组织学变化的紊乱。
目的:本体内研究的目的是确定应激诱导的抑郁症和抗抑郁药对大鼠颞下颌关节(TMJ)抑郁样行为、微观结构和组织形态的影响。方法:在用两种抗抑郁药治疗前,建立大鼠实验性抑郁模型;艾司西酞普兰(选择性血清素再摄取抑制剂)和阿托莫西汀(去甲肾上腺素再摄取抑制剂。采用微型计算机断层扫描(Micro-CT)测量髁突骨体积和骨孔隙率的变化。对髁突软骨进行了进一步的组织学评估。结果:显微CT扫描显示抑郁组骨体积减少。与对照组和抑郁症组相比,艾司西酞普兰和阿托莫西汀组的骨孔隙率均显著增加。组织病理学分析显示抑郁症组软骨层厚度增加。在阿托莫西汀组中,肥大前和肥大层厚度和细胞计数显著增加,但蛋白多糖显著减少。结论:本研究结果表明抑郁症组颞下颌关节的特点发生了变化,尤其是髁突头浅部。就不同抗抑郁药的适用性而言,阿托莫西汀治疗抑郁症最不利的原因是骨质疏松和软骨髁的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of oral science
Journal of oral science DENTISTRY, ORAL SURGERY & MEDICINE-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
3.80
自引率
0.00%
发文量
58
期刊介绍: Information not localized
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