The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2023-07-01 DOI:10.1016/j.yfrne.2023.101078

Gregory H. Jones , Omar F. Pinjari , Courtney M. Vecera , Kacy Smith , Anita Barrera , Rodrigo Machado-Vieira

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Abstract

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with significant psychosocial and medical disease burden. Much difficulty has been encountered in developing novel therapeutics and objective biomarkers for clinical use in this population. In that regard, gut-microbial homeostasis appears to modulate several key pathways relevant to a variety of psychiatric, metabolic, and inflammatory disorders. Microbial impact on immune, endocrine, endocannabinoid, kynurenine, and other pathways are discussed throughout this review. Emphasis is placed on this system’s relevance to current pharmacology, diet, and comorbid illness in bipolar disorder. Despite the high level of optimism promoted in many reviews on this topic, substantial obstacles exist before any microbiome-related findings can provide meaningful clinical utility. Beyond a comprehensive overview of pathophysiology, this review hopes to highlight several key areas where progress is needed. As well, novel microbiome-associated suggestions are presented for future research.

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肠道微生物组在双相情感障碍及其常见医学合并症中的作用

双相情感障碍是一种明显的异质性和多因素疾病，具有显著的心理社会和医疗疾病负担。在开发新的治疗方法和用于该人群临床的客观生物标志物方面遇到了很多困难。在这方面，肠道微生物稳态似乎调节了与各种精神、代谢和炎症疾病相关的几个关键途径。微生物对免疫、内分泌、内源性大麻素、犬尿氨酸和其他途径的影响在本综述中进行了讨论。强调该系统与当前双相情感障碍的药理学、饮食和共病的相关性。尽管在许多关于这一主题的综述中提倡高度乐观，但在任何与微生物组相关的发现能够提供有意义的临床实用性之前，都存在着巨大的障碍。除了对病理生理学的全面概述外，这篇综述还希望强调几个需要取得进展的关键领域。此外，还为未来的研究提出了与微生物组相关的新建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.