AI-based AlphaFold2 significantly expands the structural space of the autophagy pathway.

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2023-12-01 Epub Date: 2023-07-30 DOI:10.1080/15548627.2023.2238578

Nidhi Malhotra, Shantanu Khatri, Ajit Kumar, Akanksha Arun, Purba Daripa, Saman Fatihi, Sureshkumar Venkadesan, Niyati Jain, Lipi Thukral

引用次数: 0

Abstract

Abbreviations: AF2: AlphaFold2; AF2-Mult: AlphaFold2 multimer; ATG: autophagy-related; CTD: C-terminal domain; ECTD: extreme C-terminal domain; FR: flexible region; MD: molecular dynamics; NTD: N-terminal domain; pLDDT: predicted local distance difference test; UBL: ubiquitin-like.

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基于人工智能的AlphaFold2显著扩展了自噬途径的结构空间。

缩写：AF2:AlphaFold2；AF2多聚体：AlphaFold2多聚体；ATG：自噬相关；CTD：C端结构域；ECTD：极端C端结构域；FR：柔性区域；MD：分子动力学；NTD:N端结构域；pLDDT：预测局部距离差检验；UBL：泛素样。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.