Recent progress in type 1 classical dendritic cell cross-presentation - cytosolic, vacuolar, or both?

IF 6.6 2区 医学 Q1 IMMUNOLOGY
Ray A Ohara, Kenneth M Murphy
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引用次数: 1

Abstract

Type 1 classical dendritic cells (cDC1s) have emerged as the major antigen-presenting cell performing cross-presentation (XP) in vivo, but the antigen-processing pathway in this cell remains obscure. Two competing models for in vivo XP of cell-associated antigens by cDC1 include a vacuolar pathway and cytosolic pathway. A vacuolar pathway relies on directing antigens captured in vesicles toward a class I major histocompatibility complex loading compartment independently of cytosolic entry. Alternate proposals invoke phagosomal rupture, either constitutive or triggered by spleen tyrosine kinase (SYK) signaling in response to C-type lectin domain family 9 member A (CLEC9A) engagement, that releases antigens into the cytosol for proteasomal degradation. The Beige and Chediak–Higashi (BEACH) protein WD repeat- and FYVE domain-containing protein 4 (WDFY4) is strictly required for XP of cell-associated antigens in vivo. However, the cellular mechanism for WDFY4 activity remains unknown and its requirement in XP in vivo is currently indifferent regarding the vacuolar versus cytosolic pathways. Here, we review the current status of these models and discuss the need for future investigation.

1型经典树突状细胞交叉呈递的最新进展——胞质、液泡还是两者兼有?
1型经典树突状细胞(cDC1s)已成为体内进行交叉呈递(XP)的主要抗原呈递细胞,但该细胞中的抗原处理途径仍不清楚。cDC1对细胞相关抗原的体内XP的两个竞争模型包括液泡途径和胞质途径。液泡途径依赖于将囊泡中捕获的抗原导向I类主要组织相容性复合体装载区,而与胞质进入无关。替代方案援引吞噬体破裂,其是组成性的或由脾脏酪氨酸激酶(SYK)信号触发的,以响应C型凝集素结构域家族9成员A(CLEC9A)的参与,将抗原释放到胞质溶胶中进行蛋白酶体降解。米色和Chediak–Higashi(BEACH)蛋白质WD重复序列和含有FYVE结构域的蛋白质4(WDFY4)是体内细胞相关抗原XP的严格要求。然而,WDFY4活性的细胞机制仍然未知,其在体内XP中的需求目前对液泡途径与胞浆途径无关。在这里,我们回顾了这些模型的现状,并讨论了未来调查的必要性。
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来源期刊
CiteScore
13.30
自引率
1.40%
发文量
94
审稿时长
67 days
期刊介绍: Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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