Visualising tapasin- and TAPBPR-assisted editing of major histocompatibility complex class-I immunopeptidomes

IF 6.6 2区 医学 Q1 IMMUNOLOGY
Andy van Hateren , Tim Elliott
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引用次数: 0

Abstract

Which peptides are selected for presentation by major histocompatibility complex class-I (MHC-I) molecules is a key determinant of successful immune responses. Peptide selection is co-ordinated by the tapasin and TAP Binding PRotein (TAPBPR) proteins, which ensure MHC-I molecules preferentially acquire high-affinity-binding peptides. New structural analyses have offered insight into how tapasin achieves this function within the peptide-loading complex (PLC) (comprising the Transporter associated with Antigen Presentation (TAP) peptide transporter, tapasin–ERp57, MHC-I and calreticulin), and how TAPBPR performs a peptide editing function independently of other molecules. The new structures reveal nuances in how tapasin and TAPBPR interact with MHC-I, and how calreticulin and ERp57 complement tapasin to exploit the plasticity of MHC-I molecules to achieve peptide editing.

可视化tapasin和TAPBPR辅助编辑主要组织相容性复合体I类免疫肽
选择哪些肽由主要组织相容性复合体I类(MHC-I)分子呈递是成功免疫反应的关键决定因素。肽选择由tapasin和TAP结合蛋白(TAPBPR)蛋白协调,这确保MHC-I分子优先获得高亲和力结合肽。新的结构分析深入了解了tapasin如何在肽负载复合物(PLC)(包括与抗原呈递相关的转运蛋白(TAP)肽转运蛋白、tapasin–ERp57、MHC-I和钙网蛋白)中实现这一功能,以及TAPBPR如何独立于其他分子执行肽编辑功能。新的结构揭示了tapasin和TAPBPR如何与MHC-I相互作用的细微差别,以及钙网蛋白和ERp57如何补充tapasin以利用MHC-I分子的可塑性来实现肽编辑。
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来源期刊
CiteScore
13.30
自引率
1.40%
发文量
94
审稿时长
67 days
期刊介绍: Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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