Neonatal bilateral whisker trimming in male mice age-dependently alters brain neurotransmitter levels and causes adolescent onsets of social behavior abnormalities.

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Hiroyasu Murasawa, Hitomi Soumiya, Hiroyuki Kobayashi, Jun Imai, Takahiko Nagase, Hidefumi Fukumitsu
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引用次数: 0

Abstract

Tactile perception via whiskers is important in rodent behavior. Whisker trimming during the neonatal period affects mouse behaviors related to both whisker-based tactile cognition and social performance. However, the molecular basis of these phenomena is not completely understood. To solve this issue, we investigated developmental changes in transmitters and metabolites in various brain regions of male mice subjected to bilateral whisker trimming during the neonatal period (10 days after birth [BWT10 mice]). We discovered significantly lower levels of 3-methoxy-4-hydroxyphenyl glycol (MHPG), the major noradrenaline metabolite, in various brain regions of male BWT10 mice at both early/late adolescent stages (at P4W and P8W). However, reduced levels of dopamine (DA) and their metabolites were more significantly identified at P8W in the nuclear origins of monoamine (midbrain and medulla oblongata) and the limbic system (frontal cortex, amygdala, and hippocampus) than at P4W. Furthermore, the onset of social behavior deficits (P6W) was observed later to the impairment of whisker-based tactile cognitive behaviors (P4W). Taken together, these findings suggest that whisker-mediated tactile cognition may contribute toprogressive abnormalities in social behaviors in BWT10 mice accompanied by impaired development of dopaminergic systems.

雄性小鼠的新生双侧须修剪会随年龄改变脑神经递质水平,并导致青少年社会行为异常。
触须在啮齿动物的行为中起着重要的作用。新生期须修剪影响小鼠基于须的触觉认知和社会表现的相关行为。然而,这些现象的分子基础尚未完全了解。为了解决这一问题,我们研究了在新生儿期(出生后10天[BWT10小鼠])进行双侧胡须修剪的雄性小鼠各脑区递质和代谢物的发育变化。我们发现雄性BWT10小鼠在青春期早期/晚期(P4W和P8W)的各个脑区中,主要的去甲氧基-4-羟基苯基乙二醇(MHPG)水平显著降低。然而,与P4W相比,P8W时单胺核起源(中脑和延髓)和边缘系统(额叶皮质、杏仁核和海马体)的多巴胺(DA)及其代谢物水平的降低更为显著。此外,社交行为缺陷(P6W)的发生要晚于基于须的触觉认知行为(P4W)的损害。综上所述,这些发现表明,须介导的触觉认知可能导致BWT10小鼠社会行为的进行性异常,并伴有多巴胺能系统发育受损。
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来源期刊
Biomedical Research-tokyo
Biomedical Research-tokyo 医学-医学:研究与实验
CiteScore
2.40
自引率
0.00%
发文量
19
审稿时长
>12 weeks
期刊介绍: Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..
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