Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials.

IF 10.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Zifan Zhao, Qin Zhao, Hu Chen, Fanfan Chen, Feifei Wang, Hua Tang, Haibin Xia, Yongsheng Zhou, Yuchun Sun
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Abstract

Bone substitute material implantation has become an important treatment strategy for the repair of oral and maxillofacial bone defects. Recent studies have shown that appropriate inflammatory and immune cells are essential factors in the process of osteoinduction of bone substitute materials. Previous studies have mainly focused on innate immune cells such as macrophages. In our previous work, we found that T lymphocytes, as adaptive immune cells, are also essential in the osteoinduction procedure. As the most important antigen-presenting cell, whether dendritic cells (DCs) can recognize non-antigen biomaterials and participate in osteoinduction was still unclear. In this study, we found that surgical trauma associated with materials implantation induces necrocytosis, and this causes the release of high mobility group protein-1 (HMGB1), which is adsorbed on the surface of bone substitute materials. Subsequently, HMGB1-adsorbed materials were recognized by the TLR4-MYD88-NFκB signal axis of dendritic cells, and the inflammatory response was activated. Finally, activated DCs release regeneration-related chemokines, recruit mesenchymal stem cells, and initiate the osteoinduction process. This study sheds light on the immune-regeneration process after bone substitute materials implantation, points out a potential direction for the development of bone substitute materials, and provides guidance for the development of clinical surgical methods.

Abstract Image

树突状细胞在myd88介导的免疫识别和生物材料植入引发的骨诱导中的作用。
骨替代物植入术已成为修复口腔颌面骨缺损的重要治疗策略。近年来的研究表明,适当的炎症细胞和免疫细胞是骨替代材料成骨过程中必不可少的因素。以往的研究主要集中在巨噬细胞等先天免疫细胞上。在我们之前的工作中,我们发现T淋巴细胞,作为适应性免疫细胞,在骨诱导过程中也是必不可少的。树突状细胞作为最重要的抗原呈递细胞,其能否识别非抗原生物材料并参与骨诱导尚不清楚。在本研究中,我们发现与材料植入相关的手术创伤会引起细胞坏死,从而导致高迁移率基团蛋白-1 (HMGB1)的释放,该蛋白被吸附在骨替代材料表面。随后,hmgb1吸附的物质被树突状细胞的TLR4-MYD88-NFκB信号轴识别,炎症反应被激活。最后,活化的dc释放再生相关的趋化因子,招募间充质干细胞,并启动骨诱导过程。本研究揭示了骨替代材料植入后的免疫再生过程,为骨替代材料的发展指明了潜在的方向,为临床手术方法的发展提供指导。
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来源期刊
International Journal of Oral Science
International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
31.80
自引率
1.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.
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