Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen: more than a key mediator of viral persistence

IF 5.7 2区 医学 Q1 VIROLOGY
Thomas F Schulz , Anika Freise , Saskia C Stein
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引用次数: 0

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus-8, is an oncogenic herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of KSHV in latently infected cells. LANA mediates replication of the latent viral genome during the S phase of a dividing cell and partitions episomes to daughter cells by attaching them to mitotic chromosomes. It also mediates the establishment of latency in newly infected cells through epigenetic mechanisms and suppresses the activation of the productive replication cycle. Furthermore, LANA promotes the proliferation of infected cell by acting as a transcriptional regulator and by modulating the cellular proteome through the recruitment of several cellular ubiquitin ligases. Finally, LANA interferes with the innate and adaptive immune system to facilitate the immune escape of infected cells.

卡波西肉瘤相关疱疹病毒潜伏期相关核抗原:不仅仅是病毒持久性的关键介质
卡波西肉瘤相关疱疹病毒(KSHV),或称人类疱疹病毒-8,是一种致癌疱疹病毒。其潜伏相关核抗原(LANA)对于KSHV在潜伏感染细胞中的持久性至关重要。LANA在分裂细胞的S期介导潜在病毒基因组的复制,并通过将外泌体连接到有丝分裂染色体上将外泌体分配给子细胞。它还通过表观遗传学机制介导新感染细胞中潜伏期的建立,并抑制生产性复制周期的激活。此外,LANA通过充当转录调节因子和通过募集几种细胞泛素连接酶调节细胞蛋白质组来促进感染细胞的增殖。最后,LANA干扰先天和适应性免疫系统,促进受感染细胞的免疫逃逸。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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