Risk factors for gut colonization with vancomycin-resistant enterococci among Bulgarian critically ill patients.

IF 4.3 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Preslava M Hristova, Teodora V Marinova-Bulgaranova, Tanya V Strateva, Stefan V Trifonov, Hristina Y Hitkova
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Abstract

Vancomycin-resistant enterococci (VRЕ) are recognized as important hospital pathogens which have become common in patients admitted to the intensive care units (ICUs). The purpose of this study was to evaluate the incidence of and the risk factors for colonization with VRE among ICU patients. A total of 91 patients who had duration of hospitalization more than 48 h and without infection caused by VRE or/and other microorganisms in the ICU at University Hospital, Pleven were screened for colonization with VRE. The following data were collected: demographic characteristics, clinical information and antimicrobials use. The statistical analysis was performed using SPSS version 27.0. Colonization with VRE was established in 22 patients and one was carrying two enterococcal species. A total of 23 VRE were isolated. The univariate analysis showed that the postoperative critical cares (p < 0.001), cardiovascular diseases (p = 0.009) and the presence of an endotracheal tube (p = 0.003) were risk factors for colonization with VRE. Also, the postoperative critical cares (p = 0.021) and cardiovascular diseases (p = 0.018) were confirmed as independent risk factor for VRE acquisition by multivariate analysis. The prevalence of VRE colonization among the ICU patients was relatively high (24.2%). Risk factors for acquisition of intestinal VRE were the postoperative cares, cardiovascular diseases and the presence of an endotracheal tube.

保加利亚危重病人肠道定植万古霉素耐药肠球菌的危险因素
万古霉素耐药肠球菌(VRЕ)被认为是重要的医院病原体,在重症监护病房(icu)住院患者中已变得常见。本研究的目的是评估ICU患者VRE定植的发生率及其危险因素。选取普列文大学医院ICU住院时间超过48 h且无VRE感染或/和其他微生物感染的91例患者进行VRE定植筛查。收集以下数据:人口统计学特征、临床信息和抗菌素使用情况。采用SPSS 27.0版本进行统计分析。在22例患者中发现VRE定植,其中1例携带两种肠球菌。共分离出23例VRE。单因素分析显示,术后重症监护(p
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来源期刊
Gut Pathogens
Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY
CiteScore
7.70
自引率
2.40%
发文量
43
期刊介绍: Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).
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