Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries.

IF 2.5 4区医学 Q2 Dentistry

Brazilian Oral Research Pub Date : 2023-01-01 DOI:10.1590/1807-3107bor-2023.vol37.0076

Lívia Azeredo Alves Antunes, Walter Fialho, Thais de Oliveira Fernandes, Camila Duarte, Jhenyfer da Silva Tavares, Erika Calvano Küchler, Leonardo Santos Antunes

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Abstract

This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two-five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms: MTR (rs1805087) and MTRR (rs1801394). Mann-Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p≤0.05. MTR (rs1805087) was found associated (p = 0.05) with children's OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.

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MTR和MTRR基因与龋齿儿童口腔健康相关生活质量的关系

本研究旨在评估MTR和MTRR基因多态性是否为龋儿童口腔健康相关生活质量(OHRQoL)的潜在生物标志物。设计了一项横断面研究，其中选择了父母/照顾者和儿童(2 - 5岁)。采用临床检查检测龋病，将龋病分为低严重程度和高严重程度。采用儿童早期口腔健康影响量表(ECOHIS)评估OHRQoL。从唾液中提取基因组DNA，分析两个错义遗传多态性:MTR (rs1805087)和MTRR (rs1801394)。采用Mann-Whitney非参数检验对候选基因进行OHRQoL量表和结构域分析，显著性水平p≤0.05。在优势模型(GG + AG)中，MTR (rs1805087)与儿童OHRQoL分量表得分相关(p = 0.05)。MTR基因多态性可能增加龋齿儿童OHRQoL差的风险。需要进一步研究遗传学、分子因素和OHRQoL。

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