Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?

IF 3.4 Q2 GASTROENTEROLOGY & HEPATOLOGY
Emiko Mizoguchi, Takayuki Sadanaga, Toshiyuki Okada, Takanori Minagawa, Jun Akiba
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引用次数: 0

Abstract

Caffeine (1,3,7-trimethylxanthine, also abbreviated to CAF) is a natural chemical with stimulant effects and is commonly included in many drinks and foods, including coffee, tea, cola, energy drinks, cocoa, chocolates, and so on. Our group previously reported that oral administration of CAF efficiently suppressed the development of intestinal inflammation in a dextran sulfate sodium (DSS)-induced murine acute colitis model by suppressing the expression of chitinase 3-like 1, one of the mammalian chitinases without enzymatic activity. Chitinases are hydrolytic enzymes that break down chitin, a polymer of N-acetylglucosamine, and chitinase-like proteins have no enzymatic activity with preserving chitin-binding ability. CAF binds a cleft of the chitinase active site and plays a role as a pan-chitinase inhibitor. Although CAF showed an anti-inflammatory effect in the above model, oral administration of low-dose CAF with 10% sucrose showed potentially neoplastic effects in colonic epithelial cells in a DSS-induced murine chronic colitis model. In this review, we would like to discuss the pros and cons of coffee/CAF in colonic inflammation and neoplasia with an example of pathological finding.

Abstract Image

Abstract Image

咖啡因对结肠炎症和癌变有双刃剑作用吗?
咖啡因(1,3,7-三甲基黄嘌呤,也缩写为CAF)是一种具有兴奋作用的天然化学物质,通常包含在许多饮料和食品中,包括咖啡、茶、可乐、能量饮料、可可、巧克力等。本小组先前报道,口服CAF通过抑制几丁质酶3-like 1(一种没有酶活性的哺乳动物几丁质酶)的表达,有效地抑制了葡聚糖硫酸钠(DSS)诱导的小鼠急性结肠炎模型中肠道炎症的发展。几丁质酶是分解几丁质的水解酶,几丁质是一种n-乙酰氨基葡萄糖的聚合物,几丁质酶样蛋白质没有酶活性,但保留了几丁质结合能力。CAF结合几丁质酶活性位点的裂缝,发挥泛几丁质酶抑制剂的作用。尽管CAF在上述模型中显示出抗炎作用,但在dss诱导的小鼠慢性结肠炎模型中,口服低剂量CAF加10%蔗糖对结肠上皮细胞显示出潜在的肿瘤作用。在这篇综述中,我们想通过一个病理发现的例子来讨论咖啡/CAF在结肠炎症和肿瘤中的利弊。
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来源期刊
Intestinal Research
Intestinal Research GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
7.40
自引率
10.20%
发文量
69
审稿时长
38 weeks
期刊介绍: Intestinal Research (Intest Res) is the joint official publication of the Asian Organization for Crohn''s and Colitis (AOCC), Chinese Society of IBD (CSIBD), Japanese Society for IBD (JSIBD), Korean Association for the Study of Intestinal Diseases (KASID), Taiwan Society of IBD (TSIBD) and Colitis Crohn''s Foundation (India) (CCF, india). The aim of the Journal is to provide broad and in-depth analysis of intestinal diseases, especially inflammatory bowel disease, which shows increasing tendency and significance. As a Journal specialized in clinical and translational research in gastroenterology, it encompasses multiple aspects of diseases originated from the small and large intestines. The Journal also seeks to propagate and exchange useful innovations, both in ideas and in practice, within the research community. As a mode of scholarly communication, it encourages scientific investigation through the rigorous peer-review system and constitutes a qualified and continual platform for sharing studies of researchers and practitioners. Specifically, the Journal presents up-to-date coverage of medical researches on the physiology, epidemiology, pathophysiology, clinical presentations, and therapeutic interventions of the intestinal diseases. General topics of interest include inflammatory bowel disease, colon and small intestine cancer or polyp, endoscopy, irritable bowel syndrome and other motility disorders, infectious enterocolitis, intestinal tuberculosis, and so forth. The Journal publishes diverse types of academic materials such as editorials, clinical and basic reviews, original articles, case reports, letters to the editor, brief communications, perspective, statement or commentary, and images that are useful to clinicians and researchers.
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