Exosomes: Another intercellular lipometabolic communication mediators in digestive system neoplasms?

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI:10.1016/j.cytogfr.2023.06.005

Shaodong Li , Ruizhi Dong , Zhenhua Kang , Hucheng Li , Xueliang Wu , Tian Li

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引用次数: 5

Abstract

Neoplasms are one of the most concerned public health problems worldwide. Digestive system neoplasms, with a high morbidity and mortality, is one of the most common malignant tumors in human being. It is found that exosomes act as an intercellular communication media to carry the metabolic and genetic information of parental cells to target cells. Likely, exosomes participate in lipid metabolism and regulates multiple processes in digestive system neoplasms, including the information transmission among cancer cells, the formation of neoplastic microenvironment, and the neoplastic biological behaviors like metastasis, invasion, and the chemotherapy resistance. In this review, we firstly introduce the main mechanisms whereas exosomes act as intercellular lipometabolic communication mediator in digestive system neoplasms. Thereafter we introduce the relationship between exosomes lipid metabolism and various type of digestive system neoplasms, including gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. Eventually, we summarized and prospected the development and implication of exosomes in digestive system neoplasms. The further research of exosomes as intercellular lipid metabolism mediator will contribute to accurate and efficient diagnosis and treatment of digestive system neoplasms.

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外泌体：消化系统肿瘤中的另一种细胞间脂肪代谢通讯介质？

肿瘤是世界范围内最受关注的公共卫生问题之一。消化系统肿瘤是人类最常见的恶性肿瘤之一，具有较高的发病率和死亡率。研究发现，外泌体作为细胞间通讯介质，将亲代细胞的代谢和遗传信息传递给靶细胞。外泌体可能参与消化系统肿瘤的脂质代谢并调节多种过程，包括癌症细胞之间的信息传递、肿瘤微环境的形成以及肿瘤的生物学行为，如转移、侵袭和化疗耐药性。在这篇综述中，我们首先介绍了外泌体在消化系统肿瘤中作为细胞间脂肪代谢通讯介质的主要机制。随后，我们介绍了外泌体脂质代谢与各种消化系统肿瘤之间的关系，包括胃癌症、肝细胞癌、癌症胰腺癌和癌症结直肠癌。最后，我们总结并展望了外泌体在消化系统肿瘤中的发展和应用。外泌体作为细胞间脂质代谢介质的进一步研究将有助于准确有效地诊断和治疗消化系统肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.