Jiaying Ma, Huijia Xie, Chengxiang Yuan, Jie Shen, Jiaxin Chen, Qionglei Chen, Jiaming Liu, Qiuling Tong, Jing Sun
{"title":"The gut microbial signatures of patients with lacunar cerebral infarction.","authors":"Jiaying Ma, Huijia Xie, Chengxiang Yuan, Jie Shen, Jiaxin Chen, Qionglei Chen, Jiaming Liu, Qiuling Tong, Jing Sun","doi":"10.1080/1028415X.2023.2242121","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence revealed that gut microbial dysbiosis is involved in the pathogenesis of multiple neurological diseases, but there is little available data on the relationship between gut microbiota and lacunar cerebral infarction (LCI).</p><p><strong>Methods: </strong>Fecal samples from acute LCI patients (<i>n</i> = 65) and matched healthy controls (<i>n</i> = 65) were collected. The compositions and potential functions of the gut microbiota were estimated.</p><p><strong>Results: </strong>The results showed that there were significant gut microbial differences between LCI and control groups. Patients with LCI had higher abundances of genus <i>Lactobacillus</i>, <i>Streptococcus</i>, <i>Veillonella</i>, <i>Acidaminococcus</i>, <i>Bacillus</i>, <i>Peptoclostridium</i>, <i>Intestinibacter</i>, <i>Alloscardovia</i> and <i>Cloacibacillus</i> but lower proportions of genus <i>Agathobacter</i> and <i>Lachnospiraceae</i>_UCG-004. Investigating further these microbes such as <i>Lactobacillus</i> and <i>Veillonella</i> were correlated with clinical signs. Moreover, we found that 9 gene functions of gut microbiota were different between LCI patients and controls, which were associated with amino acid metabolism and inflammatory signal transduction. Notably, four optimal microbial markers were determined, and the combination of <i>Streptococcus</i>, <i>Lactobacillus</i>, <i>Agathobacter</i>, <i>Lachnospiraceae</i>_UCG-004 and the three risk factors achieved an area under the curve (AUC) value of 0.854 to distinguish LCI from controls.</p><p><strong>Conclusion: </strong>These findings revealed the characterizing of gut microbiota in LCI patients and provided potential microbial biomarkers for clinical diagnosis of LCI.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutritional Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1028415X.2023.2242121","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/4 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Emerging evidence revealed that gut microbial dysbiosis is involved in the pathogenesis of multiple neurological diseases, but there is little available data on the relationship between gut microbiota and lacunar cerebral infarction (LCI).
Methods: Fecal samples from acute LCI patients (n = 65) and matched healthy controls (n = 65) were collected. The compositions and potential functions of the gut microbiota were estimated.
Results: The results showed that there were significant gut microbial differences between LCI and control groups. Patients with LCI had higher abundances of genus Lactobacillus, Streptococcus, Veillonella, Acidaminococcus, Bacillus, Peptoclostridium, Intestinibacter, Alloscardovia and Cloacibacillus but lower proportions of genus Agathobacter and Lachnospiraceae_UCG-004. Investigating further these microbes such as Lactobacillus and Veillonella were correlated with clinical signs. Moreover, we found that 9 gene functions of gut microbiota were different between LCI patients and controls, which were associated with amino acid metabolism and inflammatory signal transduction. Notably, four optimal microbial markers were determined, and the combination of Streptococcus, Lactobacillus, Agathobacter, Lachnospiraceae_UCG-004 and the three risk factors achieved an area under the curve (AUC) value of 0.854 to distinguish LCI from controls.
Conclusion: These findings revealed the characterizing of gut microbiota in LCI patients and provided potential microbial biomarkers for clinical diagnosis of LCI.
期刊介绍:
Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.