One undescribed glycoside benzofuran derivative and a new p-hydroxybenzoate glycoside from the leaves of Illicium dunnianum Tutcher

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-09-16 DOI:10.1080/14786419.2023.2216348

引用次数: 0

Abstract

One undescribed benzofuran derivative (illiciumphenolicacid A, 1) and one new phenolic glycoside (illiciumphenolicacid B, 2), together with six known compounds (3–8) were isolated from the leaves of Illicium dunnianum Tutcher. Their structures were elucidated by detailed spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR). In addition, we determined the α-glucosidase inhibitory activity of the isolates in vitro using spectrophotometric methods. Compared with the positive control acarbose (IC₅₀ 306.2 ± 4.1 μM), compounds 1–8 were shown to be moderate potential α-glucosidase inhibitory activity with IC₅₀ values in the range 380–655 μM.

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从 Illicium dunnianum Tutcher 的叶子中提取出一种未曾描述过的苷类苯并呋喃衍生物和一种新的对羟基苯甲酸苷。

从 Illicium dunnianum Tutcher 的叶片中分离出了一种未曾描述过的苯并呋喃衍生物（illiciumphenolicacid A，1）和一种新的酚苷类化合物（illiciumphenolicacid B，2），以及六种已知化合物（3-8）。我们通过详细的光谱数据（紫外光谱、红外光谱、HR-ESI-MS、1D 和 2D NMR）阐明了这些化合物的结构。此外，我们还利用分光光度法测定了分离物的体外α-葡萄糖苷酶抑制活性。与阳性对照阿卡波糖（IC50 306.2 ± 4.1 μM）相比，化合物 1-8 具有中等潜在的 α-葡萄糖苷酶抑制活性，IC50 值在 380-655 μM 之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.