Subtyping of Non-Small Cell Lung Carcinoma into Adenocarcinoma and Squamous Cell Carcinoma by Cytological Structural Features.

IF 1.6 4区医学 Q3 PATHOLOGY

Acta Cytologica Pub Date : 2023-01-01 DOI:10.1159/000528882

Kosuke Inoue, Reiji Haba, Kana Kiyonaga, Toru Matsunaga, Seiko Kagawa, Toshitetsu Hayashi, Ryou Ishikawa

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引用次数: 0

Abstract

Introduction: This study aimed to clarify the diagnostic structural features in cytology specimens that are useful in subtyping non-small cell lung carcinoma (NSCLC) into adenocarcinoma (ADC) and squamous cell carcinoma (SQCC).

Methods: Cytology specimens (n = 233) of NSCLCs, which included ADCs (n = 149) and SQCCs (n = 84), were analyzed. The following cytological features were evaluated: isolated cell, flat sheet, three-dimensional cluster with irregular arrangement, papillary-like structure, micropapillary-like structure, acinar-like structure, palisading pattern, protrusion of nuclei at the periphery of the cluster, honeycomb pattern, streaming arrangement, three-dimensional sheets with regular arrangement, flattening at the periphery of the cluster, fuzzy pattern at the periphery of the cluster, and mutual inclusion.

Results: ADCs exhibited significantly higher frequencies of flat sheet (p < 0.001), papillary-like structure (p < 0.001), micropapillary-like structure (p = 0.028), acinar-like structure (p < 0.001), and protrusion of nuclei at the periphery of the cluster (p < 0.001) than SQCCs. The latter exhibited significantly higher frequencies of streaming arrangement (p < 0.001), three-dimensional sheets with regular arrangement (p < 0.001), flattening at the periphery of the cluster (p < 0.001), fuzzy pattern at the periphery of the cluster (p < 0.001), and mutual inclusion (p < 0.001) than ADCs.

Discussion: Cytological structural features, such as flat sheet, papillary-like structure, micropapillary-like structure, acinar-like structure, and protrusion of nuclei at the periphery of the cluster, indicated ADC, whereas streaming arrangement, three-dimensional sheets with regular arrangement, flattening at the periphery of the cluster, fuzzy pattern at the periphery of the cluster, and mutual inclusion indicated SQCC. Paying attention to these cytological structural features can enable the accurate subtyping of NSCLC into ADC and SQCC.

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非小细胞肺癌的细胞学结构特征分型为腺癌和鳞状细胞癌。

本研究旨在阐明细胞学标本的诊断结构特征，这些特征有助于将非小细胞肺癌(NSCLC)分为腺癌(ADC)和鳞状细胞癌(SQCC)。方法:对233例非小细胞肺癌细胞学标本进行分析，其中adc(149例)和sqcc(84例)。评价细胞的以下细胞学特征:孤立细胞、扁平片、排列不规则的三维簇、乳头状结构、微乳头状结构、腺泡状结构、栅栏状、簇周核突出、蜂窝状、流状排列、排列规则的三维片、簇周扁平、簇周模糊、相互包涵。结果:adc的扁平状结构(p < 0.001)、乳头状结构(p < 0.001)、微乳头状结构(p = 0.028)、腺泡状结构(p < 0.001)和簇周核突出(p < 0.001)的频率显著高于sqcc。与adc相比，后者表现出更高的流排列频率(p < 0.001)、排列规则的三维薄片频率(p < 0.001)、集群外围的平坦(p < 0.001)、集群外围的模糊模式(p < 0.001)和相互包含(p < 0.001)。讨论:细胞学结构特征如扁平片状、乳头状结构、微乳头状结构、腺泡状结构、簇周核突出提示ADC，而流状排列、排列规则的三维片状、簇周扁平、簇周模糊、相互包涵提示SQCC。关注这些细胞学结构特征可以使NSCLC准确分型为ADC和SQCC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Cytologica 生物-病理学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

4-8 weeks

期刊介绍： With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.