Incidence of Bell’s palsy after coronavirus disease (COVID-19) vaccination: a systematic review and meta-analysis

Neurologia Pub Date : 2024-11-01 DOI:10.1016/j.nrleng.2023.06.002

Atena Soltanzadi , Omid Mirmosayyeb , Amin Momeni Moghaddam , Hamed Ghoshouni , Mahsa Ghajarzadeh

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引用次数: 0

Abstract

Objective

To estimate the pooled incidence of Bell’s palsy after COVID-19 vaccination.

Methods

PubMed, Scopus, EMBASE, Web of Science, and Google Scholar were searched by 2 independent researchers. We also searched the grey literature including references of the references and conference abstracts. We extracted data regarding the total number of participants, first author, publication year, the country of origin, sex, type of vaccines, and the number of patients who developed Bell’s palsy after COVID-19 vaccination.

Results

The literature search revealed 370 articles, subsequently deleting duplicates 227 remained. After careful evaluation of the full texts, 20 articles remained for meta-analysis. The most commonly administered vaccines were Pfizer followed by Moderna.

In total, 4.54e+07 individuals received vaccines against COVID-19, and 1739 cases developed Bell’s palsy. In nine studies, controls (individuals without vaccination) were enrolled. The total number of controls was 1 809 069, of whom 203 developed Bell’s palsy. The incidence of Bell’s palsy after COVID-19 vaccines was ignorable. The odds of developing Bell’s palsy after COVID-19 vaccines was 1.02 (95% CI: 0.79-1.32) (I2 = 74.8%, P < .001).

Conclusion

The results of this systematic review and meta-analysis show that the incidence of peripheral facial palsy after COVID-19 vaccination is ignorable and vaccination does not increase the risk of developing Bell’s palsy. Maybe, Bell’s palsy is a presenting symptom of a more severe form of COVID-19, so clinicians must be aware of this.

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冠状病毒病（COVID-19）疫苗接种后贝尔麻痹的发病率：系统综述和荟萃分析

目的：估计COVID-19疫苗接种后贝尔麻痹的合并发病率。方法：由2名独立研究人员检索PubMed、Scopus、EMBASE、Web of Science、谷歌Scholar。我们还检索了灰色文献，包括参考文献和会议摘要。我们提取了有关参与者总数、第一作者、发表年份、原产国、性别、疫苗类型以及接种COVID-19疫苗后发生贝尔麻痹的患者数量的数据。结果：文献检索显示370篇，随后删除重复的227篇。经过对全文的仔细评估，剩下20篇文章用于荟萃分析。最常用的疫苗是辉瑞，其次是Moderna。总共有4.54 +07人接种了COVID-19疫苗，1739例发生了贝尔麻痹。在9项研究中，对照组（未接种疫苗的个体）被纳入。对照组总人数为189069人，其中203人发展为贝尔麻痹。接种COVID-19疫苗后贝尔麻痹的发生率可以忽略不计。接种COVID-19疫苗后发生贝尔麻痹的几率为1.02 (95% CI: 0.79-1.32) （I2 = 74.8%, P < 0.001）。结论：本系统综述和荟萃分析结果显示，COVID-19疫苗接种后周围性面瘫的发生率可以忽略不计，接种疫苗不会增加发生贝尔麻痹的风险。也许，贝尔氏麻痹是一种更严重的COVID-19的表现症状，所以临床医生必须意识到这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologia

自引率

0.00%

发文量

审稿时长

53 weeks