The alteration of serum bile acid profile among traumatic brain injury patients: a small-scale prospective study.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Yuanrun Zhu, Peidong Zheng, Yajun Lin, Juehan Wang, Wendong You, Yadong Wang, Huiqing Zheng, Liang Wen, Xiaofeng Yang
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Abstract

Traumatic brain injury is one of the major causes of morbidity and mortality worldwide. With the development of bile acids as a potential treatment, to identify the influence of traumatic brain injury on bile acid metabolism shows growing importance. This present study did a preliminary exploration of the bile acid profile alteration among traumatic brain injury patients. In total, 14 patients and 7 healthy volunteers were enrolled. The bile acid profile of the blood samples were detected by an Ultra-performance Liquid Chromatography Mass Spectrometer/Mass Spectrometer system. It was found that 6 bile acids were statistically decreased in traumatic brain injury patients comparing with healthy volunteers: glycocholic acid (median level 44.4 ng/ml vs 98.7 ng/ml, p = 0.003), taurocholic acid (median level 10.9 ng/ml vs 19.5 ng/ml, p = 0.006), glycoursodeoxycholic acid (median level 17.4 ng/ml vs 71.4 ng/ml, p = 0.001), ursodeoxycholic acid (median level <1 ng/ml vs 32.4 ng/ml, p = 0.002), taurochenodeoxycholic acid (median level <1 ng/ml vs 53.6 ng/ml, p = 0.003) and glycochenodeoxycholic acid (GCDCA, median level 160 ng/ml vs 364 ng/ml, p<0.001). In conclusion, traumatic brain injury events are able to induce bile acid metabolism alteration in plasma and might cause reduction in glycocholic, taurocholic, glycoursodeoxycholic, ursodeoxycholic, taurochenodeoxycholic and glycochenodeoxycholic acid levels.

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外伤性脑损伤患者血清胆汁酸谱的改变:一项小规模前瞻性研究。
外伤性脑损伤是全世界发病率和死亡率的主要原因之一。随着胆汁酸作为一种潜在的治疗手段的发展,确定外伤性脑损伤对胆汁酸代谢的影响显得越来越重要。本研究对外伤性脑损伤患者胆汁酸谱变化进行了初步探讨。共纳入14名患者和7名健康志愿者。采用超高效液相色谱质谱/质谱联用系统检测血液样品的胆汁酸谱。结果发现,与健康志愿者相比,外伤性脑损伤患者有6种胆汁酸含量显著降低:糖胆酸(中位水平44.4 ng/ml vs 98.7 ng/ml, p = 0.003)、牛磺酸胆酸(中位水平10.9 ng/ml vs 19.5 ng/ml, p = 0.006)、甘糖去氧胆酸(中位水平17.4 ng/ml vs 71.4 ng/ml, p = 0.001)、熊去氧胆酸(中位水平p = 0.002)、牛磺酸去氧胆酸(中位水平p = 0.003)和甘糖去氧胆酸(GCDCA,中位水平160 ng/ml vs 364 ng/ml, p = 0.003)
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来源期刊
CiteScore
4.30
自引率
8.30%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.
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