Quenching and quorum sensing in bacterial bio-films

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Research in microbiology Pub Date : 2024-03-01 DOI:10.1016/j.resmic.2023.104085

Srinivasan Kameswaran , Sudhakara Gujjala , Shaoqing Zhang , Suresh Kondeti , Sundararajan Mahalingam , Manjunatha Bangeppagari , Ramesh Bellemkonda

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引用次数: 0

Abstract

Quorum sensing (QS) is the ability of bacteria to monitor their population density and adjust gene expression accordingly. QS-regulated processes include host–microbe interactions, horizontal gene transfer, and multicellular behaviours (such as the growth and development of biofilm). The creation, transfer, and perception of bacterial chemicals known as autoinducers or QS signals are necessary for QS signalling (e.g. N-acylhomoserine lactones). Quorum quenching (QQ), another name for the disruption of QS signalling, comprises a wide range of events and mechanisms that are described and analysed in this study. In order to better comprehend the targets of the QQ phenomena that organisms have naturally developed and are currently being actively researched from practical perspectives, we first surveyed the diversity of QS-signals and QS-associated responses. Next, the mechanisms, molecular players, and targets related to QS interference are discussed, with a focus on natural QQ enzymes and compounds that function as QS inhibitors. To illustrate the processes and biological functions of QS inhibition in microbe–microbe and host–microbe interactions, a few QQ paradigms are described in detail. Finally, certain QQ techniques are offered as potential instruments in a variety of industries, including agriculture, medical, aquaculture, crop production, and anti-biofouling areas.

查看原文本刊更多论文

细菌生物膜中的猝灭和群体感应。

群体感应（QS）是细菌监测其种群密度并相应调整基因表达的能力。QS调节的过程包括宿主-微生物相互作用、水平基因转移和多细胞行为（如生物膜的生长和发育）。被称为自动诱导物或QS信号的细菌化学物质的产生、转移和感知是QS信号传导所必需的（例如N-酰基高丝氨酸内酯）。群体猝灭（QQ）是QS信号中断的另一个名称，包括本研究中描述和分析的一系列事件和机制。为了更好地理解生物体自然发展并目前正在从实践角度积极研究的QQ现象的目标，我们首先调查了QS信号和QS相关反应的多样性。接下来，讨论了QS干扰的机制、分子参与者和靶点，重点讨论了天然QQ酶和起QS抑制剂作用的化合物。为了说明QS在微生物-微生物和宿主-微生物相互作用中的抑制过程和生物学功能，详细描述了几个QQ范式。最后，某些QQ技术被提供作为各种行业的潜在工具，包括农业、医疗、水产养殖、作物生产和防生物污染领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in microbiology 生物-微生物学

CiteScore

4.10

自引率

3.80%

发文量

审稿时长

16 days

期刊介绍： Research in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l''Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur''s "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l''Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.