Vitamin D May Play a Vital Role in Alleviating Type 2 Diabetes Mellitus by Modulating the Ferroptosis Signaling Pathway.

IF 2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormone and Metabolic Research Pub Date : 2024-03-01 Epub Date: 2023-07-04 DOI:10.1055/a-2122-5701

Qiong-Wen Zhang, Yan Wang, Zi-Ying Tong, Cui-Ping Li, Lian-Ping He

引用次数: 0

Abstract

Ferroptosis is an iron-dependent death mode mediated by the aggregation of lipid peroxides and lipid-reactive oxygen species. It is characterized by iron-dependent lipid peroxide accumulation accompanied by oxidoreductase deficiency. Pancreatic beta cell dysfunction and insulin resistance are two major causes of type 2 diabetes mellitus (T2DM). Iron accumulation and metabolism may play a role in the development of T2DM. The molecular mechanism of β cell apoptosis and iron death in T2DM were reviewed. In addition, we discuss recent insights on the relationship between the trace element iron and apoptosis of β cells in T2DM.

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维生素 D 可通过调节铁氧化酶信号通路在缓解 2 型糖尿病中发挥重要作用

铁变态反应是一种由脂质过氧化物和脂质活性氧聚集介导的铁依赖性死亡模式。其特点是铁依赖性脂质过氧化物积累，同时伴有氧化还原酶缺乏。胰岛β细胞功能障碍和胰岛素抵抗是导致 2 型糖尿病（T2DM）的两个主要原因。铁的积累和代谢可能在 T2DM 的发病过程中起作用。我们回顾了T2DM中β细胞凋亡和铁死亡的分子机制。此外，我们还讨论了微量元素铁与 T2DM 中 β 细胞凋亡之间关系的最新见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone and Metabolic Research 医学-内分泌学与代谢

CiteScore

3.80

自引率

0.00%

发文量

125

审稿时长

3-8 weeks

期刊介绍： Covering the fields of endocrinology and metabolism from both, a clinical and basic science perspective, this well regarded journal publishes original articles, and short communications on cutting edge topics. Speedy publication time is given high priority, ensuring that endocrinologists worldwide get timely, fast-breaking information as it happens. Hormone and Metabolic Research presents reviews, original papers, and short communications, and includes a section on Innovative Methods. With a preference for experimental over observational studies, this journal disseminates new and reliable experimental data from across the field of endocrinology and metabolism to researchers, scientists and doctors world-wide.