SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1.

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2023-12-01 Epub Date: 2023-07-23 DOI:10.1080/15548627.2023.2238579

Pengtao Jiao, Wenhui Fan, Xiaoya Ma, Runshan Lin, Yuna Zhao, Yabo Li, He Zhang, Xiaojuan Jia, Yuhai Bi, Xiaoli Feng, Minghua Li, Wenjun Liu, Ke Zhang, Lei Sun

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引用次数: 1

Abstract

Abbreviations: aa: amino acid; ATF6: activating transcription factor 6; ATG5: autophagy related 5; CCPG1: cell cycle progression 1; CFTR: CF transmembrane conductance regulator; cGAMP: cyclic GMP-AMP; CGAS: cyclic GMP-AMP synthase; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; EIF2A/eIF2α: eukaryotic translation initiation factor 2A; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; ER: endoplasmic reticulum; ERN1/IRE1: endoplasmic reticulum to nucleus signaling 1; GFP: green fluorescent protein; HSPA5/GRP78: heat shock protein family A (Hsp70) member 5; HSV-1: herpes simplex virus type 1; IFIT1: interferon induced protein with tetratricopeptide repeats 1; IFNB1/IFN-β: interferon beta 1; IRF3: interferon regulatory factor 3; ISG15: ISG15 ubiquitin like modifier; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAP3K7/TAK1: mitogen-activated protein kinase kinase kinase 7; MAVS: mitochondrial antiviral signaling protein; MOI: multiplicity of infection; NFKB/NF-κB: nuclear factor kappa B; NSP6: non-structural protein 6; Δ106-108: deletion of amino acids 106-108 in NSP6 of SARS-CoV-2; Δ105-107: deletion of amino acids 105-107 in NSP6 of SARS-CoV-2; RETREG1/FAM134B: reticulophagy regulator 1; RIGI/DDX58: RNA sensor RIG-I; SQSTM1/p62: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TBK1: TANK binding kinase 1.

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严重急性呼吸系统综合征冠状病毒2型非结构蛋白6触发内质网应激诱导的自噬以降解STING1。

缩写：aa：氨基酸；ATF6：激活转录因子6；ATG5：自噬相关5；CCPG1：细胞周期进展1；CFTR：CF跨膜电导调节剂；cGAMP：环状GMP-AMP；CGAS：环状GMP-AMP合酶；CHX：环己酰亚胺；Co-IP：共免疫沉淀；CQ：氯喹；EIF2A/eIF2α：真核翻译起始因子2A；EIF2AK3/PERK：真核翻译起始因子2α激酶3；ER：内质网；ERN1/IRE1：内质网-细胞核信号传导1；GFP：绿色荧光蛋白；HSPA5/GRP78：热休克蛋白家族A（Hsp70）成员5；HSV-1：单纯疱疹病毒1型；IFIT1：干扰素诱导的具有四肽重复序列1的蛋白质；IFNB1/IFN-β：干扰素β1；IRF3：干扰素调节因子3；ISG15:ISG15泛素样修饰物；MAP1LC3B/LC3B：微管相关蛋白1轻链3β；MAP3K7/TAK1:丝裂原活化蛋白激酶激酶7；MAVS：线粒体抗病毒信号蛋白；MOI：感染的多重性；NF-κB：核因子κB；NSP6：非结构蛋白6；Δ106-108：严重急性呼吸系统综合征冠状病毒2型NSP6中氨基酸106-108的缺失；Δ105-107：严重急性呼吸系统综合征冠状病毒2型NSP6中氨基酸105-107的缺失；RETREG1/FAM134B:网状食管调节器1；RIGI/DDX58：RNA传感器RIG-I；SQSTM1/p62：螯合体1；STING1：干扰素反应刺激因子cGAMP相互作用因子1；TBK1：TANK结合激酶1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.