Stability of Symptom Clusters in Children With Acute Lymphoblastic Leukemia Undergoing Chemotherapy.

IF 2.4 3区医学 Q1 NURSING

Cancer Nursing Pub Date : 2024-09-01 Epub Date: 2023-07-31 DOI:10.1097/NCC.0000000000001261

Rongrong Li, Xinyi Shen, Qi Yang, Lin Zhang, Huiling Li, Wenying Yao, Yuying Chan

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引用次数: 0

Abstract

Background: Children with acute lymphoblastic leukemia (ALL) experience multiple symptoms during chemotherapy. Assessing how symptoms cluster together and how these symptom clusters (SCs) change over time may lay a foundation for future research in SC management and the pathophysiological mechanisms of SCs.

Objectives: This study aimed to assess the stability of SCs in children with ALL during chemotherapy.

Methods: A longitudinal investigation was carried out. The Chinese version of the Memorial Symptom Assessment Scale 10 to 18 was used to assess the occurrence, severity, and distress of symptoms in 134 children with ALL (8-16 years old) at the following 4 separate points: before chemotherapy (T1), start of post-induction therapy (T2), 4 months post-induction therapy (T3), and start of maintenance therapy (T4). Exploratory factor analyses were used to extract SCs.

Results: Six SCs were identified. Emotional and somatic clusters were identified across all dimensions and time points. Gastrointestinal cluster was all identified except for occurrence at T1. Neurological cluster was identified at T2 and T3 for all dimensions and at T4 for severity and distress. Self-image disorder cluster was all identified except at T1. Skin mucosa cluster was identified at T2 and T3 for all dimensions. Emotional cluster exhibited common symptoms across dimensions and time points.

Conclusion: The number and types of SCs determined by scoring the occurrence, severity, and distress are different, but some SCs are relatively stable.

Implications for practice: Clinicians should not only focus on the common trajectory of symptoms and SCs, but also assess each child individually.

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接受化疗的急性淋巴细胞白血病患儿症状群的稳定性。

背景：急性淋巴细胞白血病（ALL）患儿在化疗期间会出现多种症状。评估症状如何聚集在一起以及这些症状群（SCs）如何随时间发生变化，可为今后SCs管理和SCs病理生理机制的研究奠定基础：本研究旨在评估 ALL 儿童化疗期间 SCs 的稳定性：方法：进行纵向调查。采用中文版纪念性症状评估量表10-18，对134名ALL患儿（8-16岁）在化疗前（T1）、诱导后治疗开始（T2）、诱导后治疗4个月（T3）和维持治疗开始（T4）4个不同时间点的症状发生、严重程度和痛苦程度进行评估。探索性因子分析用于提取 SCs：结果：确定了六个 SC。在所有维度和时间点上都确定了情绪和躯体集群。胃肠道群组除在 T1 出现外，其余均被识别。在 T2 和 T3 的所有维度上，以及在 T4 的严重程度和痛苦程度上，均确定了神经系统群组。自我形象失调群组除在 T1 出现外，其余均被识别。皮肤粘膜组在 T2 和 T3 的所有维度上都被识别出来。在不同的维度和时间点，情绪群表现出共同的症状：结论：通过对发生率、严重程度和痛苦程度进行评分而确定的 SC 数量和类型各不相同，但有些 SC 相对稳定：临床医生不仅要关注症状和 SC 的共同轨迹，还要对每个儿童进行单独评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Nursing 医学-护理

CiteScore

4.80

自引率

3.80%

发文量

244

审稿时长

6-12 weeks

期刊介绍： Each bimonthly issue of Cancer Nursing™ addresses the whole spectrum of problems arising in the care and support of cancer patients--prevention and early detection, geriatric and pediatric cancer nursing, medical and surgical oncology, ambulatory care, nutritional support, psychosocial aspects of cancer, patient responses to all treatment modalities, and specific nursing interventions. The journal offers unparalleled coverage of cancer care delivery practices worldwide, as well as groundbreaking research findings and their practical applications.