Clinical Characteristics of Human Pulmonary Dirofilariasis in Japan: An Uncommon Differential Diagnosis of a Solitary Pulmonary Nodule.

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Japanese journal of infectious diseases Pub Date : 2023-09-22 Epub Date: 2023-05-31 DOI:10.7883/yoken.JJID.2022.617
Kengo Oshima
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引用次数: 0

Abstract

Human pulmonary dirofilariasis (HPD) is a zoonotic disease caused by Dirofilaria immitis. Most HPD cases are asymptomatic and are either detected during annual health checkups or incidentally identified during the investigation of other diseases, particularly primary or metastatic pulmonary lung cancers. However, the frequency and clinical features of Japanese patients with HPD remain unclear. We analyzed data from the Japanese Medical Abstract Society database and identified 69 cases between 1978 and 2022. The incidence of HPD increased until the 2000s but declined markedly in the 2010s. The incidence is higher in the southwestern region and lower in the northeastern region of Japan. Health checkups are the primary diagnostic opportunities. The Chugoku and Shikoku regions have had high incidence rates per population. The diagnosis of HPD using a noninvasive procedure is typically difficult because of the absence of specific clinical symptoms, and approximately 70% of the cases are detected using video-assisted thoracoscopic surgery. Climate change may increase the incidence of HPD in the northeastern region of Japan, and travel to countries with poor vector control may be a risk factor for HPD transmission. Physicians should consider this parasitic infectious disease when examining patients presenting with solitary lung nodules.

日本人肺丝虫病的临床特征:孤立性肺结节的罕见鉴别诊断。
人肺吸虫病(HPD)是一种由疟疾引起的人畜共患疾病。大多数HPD病例是无症状的,要么在年度健康检查中发现,要么在其他疾病的调查中偶然发现,特别是原发性或转移性肺肺癌。然而,日本HPD患者的发病率和临床特征尚不清楚。我们分析了日本医学文摘社数据库的数据,确定了1978年至2022年间的69例病例。HPD的发病率在2000年代之前一直在上升,但在2010年代明显下降。日本西南地区发病率较高,东北地区发病率较低。健康检查是主要的诊断机会。中部和四国地区的人均发病率很高。由于没有特定的临床症状,使用非侵入性手术诊断HPD通常很困难,大约70%的病例是通过电视胸腔镜手术发现的。气候变化可能会增加日本东北部地区HPD的发病率,前往病媒控制不力的国家可能是HPD传播的风险因素。医生在检查表现为孤立性肺结节的患者时应考虑这种寄生虫感染性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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