A single center experience in the management of progressive juvenile pilocytic astrocytoma.

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Journal of neurosurgical sciences Pub Date : 2023-06-01 DOI:10.23736/S0390-5616.21.05169-9

Ieta Shams, Branavan Manoranjan, Rebecca Voth, Malavan Ragulojan, Olufemi Ajani, Blake Yarascavitch, Sheila K Singh, Adam J Fleming

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引用次数: 0

Abstract

Background: Juvenile pilocytic astrocytoma (JPA) typically follows an indolent clinical course. The first-line treatment for most JPAs is surgical resection. However, a gross total resection may not be feasible for deep-seated lesions and/or infiltrative tumors, leading to multimodal treatment approaches that may be complicated by patient age and tumor location. Despite the prevalence of pediatric JPAs, there is no single approach to treating progressive disease.

Methods: We investigated the multifaceted management of progressive JPAs through a retrospective analysis of JPAs treated at a single center over an 18-year period (1998-2016). All cases were categorized according to location, whether supratentorial or infratentorial, and for each case we calculated the number of interventions and the time between interventions.

Results: We identified a total of 40 JPAs, (11 supratentorial, 29 infratentorial). Total number of interventions among all supratentorial JPA patients was 21 (average 2 interventions/patient). The total number of interventions among infratentorial JPAs was 40 (average 1.4 interventions/patient).

Conclusions: Treatment of progressive JPA is variable and may require numerous surgeries and adjuvant therapies.

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进行性青少年毛细胞星形细胞瘤的单中心治疗经验。

背景:青少年毛细胞星形细胞瘤(JPA)的临床过程通常是惰性的。大多数jpa的一线治疗是手术切除。然而，对于深部病变和/或浸润性肿瘤，总全切除可能不可行，导致多模式治疗方法可能因患者年龄和肿瘤位置而复杂化。尽管儿科jpa普遍存在，但没有单一的方法来治疗进行性疾病。方法:我们通过回顾性分析18年间(1998-2016年)在单一中心治疗的JPAs，研究了进行性JPAs的多方面管理。所有病例都根据位置进行分类，无论是幕上还是幕下，我们计算了每个病例的干预次数和干预间隔时间。结果:我们共发现40个jpa，(11个幕上，29个幕下)。所有幕上JPA患者的干预总数为21例(平均2例)。幕下jpa的干预总数为40例(平均1.4例/例)。结论:进行性JPA的治疗是可变的，可能需要多次手术和辅助治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neurosurgical sciences CLINICAL NEUROLOGY-SURGERY

CiteScore

3.00

自引率

5.30%

发文量

202

审稿时长

>12 weeks

期刊介绍： The Journal of Neurosurgical Sciences publishes scientific papers on neurosurgery and related subjects (electroencephalography, neurophysiology, neurochemistry, neuropathology, stereotaxy, neuroanatomy, neuroradiology, etc.). Manuscripts may be submitted in the form of ditorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.