Light-triggered cardiac microphysiological model.

IF 6.6 3区医学 Q1 ENGINEERING, BIOMEDICAL

APL Bioengineering Pub Date : 2023-06-01 DOI:10.1063/5.0143409

V Vurro, K Shani, H A M Ardoña, J F Zimmerman, V Sesti, K Y Lee, Q Jin, C Bertarelli, K K Parker, G Lanzani

引用次数: 1

Abstract

Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept, we show photostimulation of an in vitro cardiac microphysiological model mediated by an amphiphilic azobenzene compound that preferentially dwells in the cell membrane. Exploiting this optical based stimulation technology could be a disruptive approach for highly resolved cardiac tissue stimulation.

查看原文本刊更多论文

光触发心脏微生理模型。

光被认为是刺激可兴奋细胞的准确和非侵入性工具。在这里，我们报告了一种基于有机分子光换能器的非遗传方法，该方法允许无布线和无电极组织调制。作为概念的证明，我们展示了由优先居住在细胞膜上的两亲性偶氮苯化合物介导的体外心脏微生理模型的光刺激。利用这种基于光学的刺激技术可能是一种高分辨率心脏组织刺激的颠覆性方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

APL Bioengineering ENGINEERING, BIOMEDICAL-

CiteScore

9.30

自引率

6.70%

发文量

审稿时长

19 weeks

期刊介绍： APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology