Incidence and clinical characteristics of pediatric inflammatory bowel disease in Oman.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-01 DOI:10.4103/sjg.sjg_473_22

Tawfiq Taki Al Lawati, Yusriya Al Rawahi, Al Qasim Al Bahlani, Adawiya Al Jamei, Dafalla Ramatalla, Omar I Saadah

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引用次数: 0

Abstract

Background: Pediatric inflammatory bowel disease (PIBD) has been documented all over the world, and there is now a large body of clinical, pathological, and treatment knowledge and protocols in place in many countries. There is currently limited knowledge on the prevalence and pathology of PIBD in Omani population. The aim of this study is to report the incidence and clinical features of PIBD in Oman.

Methods: This was a retrospective, cross-sectional, multicenter study carried out on all children <13 years of age between January 1, 2010 and December 31, 2021.

Results: Fifty-one children were identified, 22 males (43.1%) and 29 females (56.9%), who were mostly from the Muscat region of Oman. The median incidence in the country was 0.57 (confidence interval [CI]: 0.31-0.64) per 10⁵ children for inflammatory bowel disease (IBD), 0.18 (CI: 0.07-0.38) per 10⁵ children for ulcerative colitis (UC), and 0.19 (CI: 0.12-0.33) per 10⁵ children for Crohn's disease (CD). There was a significant increase in the incidence of all PIBD types after the year 2015. Bloody diarrhea was the most common symptom, followed by abdominal pain. Perianal disease affected nine children (40.9%) with CD.

Conclusion: The incidence of PIBD in Oman is lower than in some neighboring Gulf countries but similar to that of Saudi Arabia. An alarming upward trend was noted from the year 2015. Large-scale population-based studies are required to investigate the possible causes of this increasing incidence.

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阿曼儿童炎症性肠病的发病率和临床特点

背景:儿童炎症性肠病(PIBD)在世界各地都有文献记载，现在许多国家都有大量的临床、病理和治疗知识和方案。目前对阿曼人群中PIBD的患病率和病理了解有限。本研究的目的是报告阿曼PIBD的发病率和临床特征。方法:这是一项对所有儿童进行的回顾性、横断面、多中心研究。结果:确定了51名儿童，其中22名男性(43.1%)，29名女性(56.9%)，主要来自阿曼马斯喀特地区。该国的中位发病率为每105名炎症性肠病(IBD)儿童0.57例(可信区间[CI]: 0.31-0.64)，每105名溃疡性结肠炎(UC)儿童0.18例(CI: 0.07-0.38)，每105名克罗恩病(CD)儿童0.19例(CI: 0.12-0.33)。2015年后，所有PIBD类型的发病率均有显著增加。最常见的症状是带血腹泻，其次是腹痛。结论:阿曼的PIBD发病率低于邻近的一些海湾国家，但与沙特阿拉伯相似。从2015年开始出现了令人担忧的上升趋势。需要大规模的基于人群的研究来调查这种发病率增加的可能原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.