Adenosquamous cell carcinoma of the head and neck: a retrospective single institution series.

IF 2.1 4区医学 Q2 OTORHINOLARYNGOLOGY

Acta Otorhinolaryngologica Italica Pub Date : 2023-10-01 Epub Date: 2023-07-28 DOI:10.14639/0392-100X-N2466

Gabriele Zigliani, Sara Migliorati, Elisa Marazzi, Mara Arcuri, Michele Tomasoni, Simonetta Battocchio, Alberto Paderno, Davide Lancini, Alberto Deganello, Cesare Piazza

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Abstract

Objectives: Head and neck adenosquamous cell carcinoma (HN-ASCC) is a rare, aggressive neoplasm, with limited data reported in the literature. The aim of this study was to assess tumour behaviour and prognostic factors impacting overall survival (OS) in a retrospective, single institution series.

Methods: A retrospective study on patients affected by HN-ASCC who were treated surgically between 2002 and 2019 at the Department of Otorhinolaryngology - Head and Neck Surgery of the University of Brescia was conducted. Demographics, clinical data, OS, and relative prognostic factors were analysed.

Results: The study included 32 patients, with a median age of 66 years, mostly males (84.4%) and untreated (68.8%). Adjuvant treatments followed surgery in 28.1% of patients. Compared to conventional SCC, ASCC showed a higher proportion of cases arising in the larynx (40.6%); no difference was found in other features. Advanced (pT3-4) local stage at presentation (p = 0.023), perineural invasion (PNI, p = 0.01), and positive margins (p = 0.007) were independent negative prognostic factors for OS.

Conclusions: HN-ASCC is a rare, aggressive cancer, most frequently arising in the larynx of elderly males, usually diagnosed in an advanced local stage. OS is generally poor, affected by local advanced stage, PNI, and positive resection margins.

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头颈部腺鳞状细胞癌：一个回顾性的单一机构系列。

目的：头颈部腺鳞状细胞癌（HN-ASCC）是一种罕见的侵袭性肿瘤，文献报道的数据有限。本研究的目的是在一个回顾性的单一机构系列中评估肿瘤行为和影响总生存率（OS）的预后因素。方法：对2002年至2019年间在布雷西亚大学耳鼻咽喉头颈外科接受手术治疗的HN-ASCC患者进行回顾性研究。对人口学、临床数据、OS和相关预后因素进行了分析。结果：该研究包括32名患者，中位年龄为66岁，大多数为男性（84.4%）和未经治疗的患者（68.8%）。28.1%的患者在手术后进行辅助治疗。与传统SCC相比，ASCC发生在喉部的病例比例更高（40.6%）；在其他特征上没有发现差异。OS的晚期（pT3-4）局部分期（p=0.023）、神经侵袭（PNI，p=0.01）和阳性边缘（p=0.007）是独立的阴性预后因素。结论：HN-ASCC是一种罕见的侵袭性癌症，最常见于老年男性喉部，通常诊断为局部晚期。OS通常较差，受局部晚期、PNI和阳性切除边缘的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Otorhinolaryngologica Italica OTORHINOLARYNGOLOGY-

CiteScore

3.40

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Otorhinolaryngologica Italica first appeared as “Annali di Laringologia Otologia e Faringologia” and was founded in 1901 by Giulio Masini. It is the official publication of the Italian Hospital Otology Association (A.O.O.I.) and, since 1976, also of the Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale (S.I.O.Ch.C.-F.). The journal publishes original articles (clinical trials, cohort studies, case-control studies, cross-sectional surveys, and diagnostic test assessments) of interest in the field of otorhinolaryngology as well as clinical techniques and technology (a short report of unique or original methods for surgical techniques, medical management or new devices or technology), editorials (including editorial guests – special contribution) and letters to the Editor-in-Chief. Articles concerning science investigations and well prepared systematic reviews (including meta-analyses) on themes related to basic science, clinical otorhinolaryngology and head and neck surgery have high priority.