Effect of Helicobacter pylori Eradication on Body Weight: A Multicenter Propensity Score-matched Analysis in Korea.

IF 3.3 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurogastroenterology and Motility Pub Date : 2023-07-30 DOI:10.5056/jnm22179

Jong Wook Kim, Myong Ki Baeg, Chang Seok Bang, Jong-Kyu Park, Jung-Hwan Oh, The Diet

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引用次数: 1

Abstract

Background/aims: There is growing interest in whether Helicobacter pylori eradication (HPE) can affect body weight.

Methods: Data from 5 universities between January 2013 and December 2019 were analyzed retrospectively. H. pylori-positive subjects who had body weight measurements taken at least twice at intervals of 3 months or longer were included. Using propensity score (PS)-matched data, changes in body mass index (BMI) and the lipid profile after HPE were compared with the non-HPE group.

Results: Among 363 eligible patients, 131 HPE patients were PS-matched to 131 non-HPE patients. The median intervals between the measurements were 610 (range, 154-1250) days and 606 (range, 154-1648) days in the HPE and non-HPE groups, respectively. In both groups, the mean BMI increased (from 24.5 kg/m² to 24.7 kg/m² in the HPE group, and from 24.4 kg/m² to 24.5 kg/m² in the non-HPE group). The 2 groups did not show significantly different changes (P = 0.921). In the lowest baseline BMI quartile, the BMI increased after HPE by 1.23 (standard deviation [SD], 3.72) kg/m² (P = 0.060), and the non-HPE group showed a decreased BMI at the time of follow-up (by -0.24 [SD, 5.25] kg/m²; P = 0.937) (between-group P = 0.214). Triglyceride levels increased after HPE (mean: 135 [SD, 78] to 153 [SD, 100] mg/dL; between-group P = 0.053).

Conclusion: The overall BMI change was not significantly different between the HPE and non-HPE groups, but patients with low BMI showed a tendency to gain weight after HPE. Triglyceride levels increased after HPE with marginal significance.

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根除幽门螺杆菌对体重的影响:韩国一项多中心倾向评分匹配分析。

背景/目的:根除幽门螺杆菌(Helicobacter pylori, HPE)是否会影响体重，这一点越来越引起人们的兴趣。方法:对5所高校2013年1月至2019年12月的资料进行回顾性分析。幽门螺杆菌阳性受试者，每隔3个月或更长时间至少测量两次体重。使用倾向评分(PS)匹配的数据，将HPE后的体重指数(BMI)和脂质谱的变化与非HPE组进行比较。结果:在363例符合条件的患者中，131例HPE患者与131例非HPE患者ps匹配。在HPE组和非HPE组中，测量间隔的中位数分别为610(范围154-1250)天和606(范围154-1648)天。在两组中，平均BMI均增加(HPE组从24.5 kg/m2增加到24.7 kg/m2，非HPE组从24.4 kg/m2增加到24.5 kg/m2)。两组间差异无统计学意义(P = 0.921)。在最低基线BMI四分位数中，HPE后BMI增加了1.23(标准差[SD]， 3.72) kg/m2 (P = 0.060)，非HPE组在随访时BMI下降(-0.24 [SD, 5.25] kg/m2;P = 0.937)(组间P = 0.214)。HPE后甘油三酯水平升高(平均值:135 [SD, 78]至153 [SD, 100] mg/dL;组间P = 0.053)。结论:HPE组与非HPE组总体BMI变化无显著性差异，但低BMI患者在HPE后有体重增加的趋势。HPE后甘油三酯水平升高，具有边际显著性。

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来源期刊

Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY

CiteScore

6.30

自引率

8.80%

发文量

期刊介绍： Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.