{"title":"Anxiolytic effects of vestibular stimulation: an update.","authors":"Sai Sailesh Kumar Goothy, Jason McKeown","doi":"10.1515/jbcpp-2023-0022","DOIUrl":null,"url":null,"abstract":"<p><p>The vestibular system inhibits both HPA and SAM axis and contributes to the management of anxiety. Both direct and indirect pathways exist in the inhibition of the HPA and SAM axis. In this review article, the authors describe various pathways through which the vestibular system can regulate the HPA and SAM axis activity. Lastly, the authors highlight the need of starting translational research work in this field. Rocking is soothing and this is a universal fact that babies in the swing will calm down and sleep. These soothing effects of vestibular stimulation may be due to the inhibition of cortical and subcortical structures. Vestibular stimulation may be able to manage anxiety through its connections with multiple brain areas. There is a need to undertake translational research in this area to establish strong scientific evidence and recommend implementation of the vestibular stimulation in the management of anxiety.</p>","PeriodicalId":15352,"journal":{"name":"Journal of Basic and Clinical Physiology and Pharmacology","volume":"34 4","pages":"445-449"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Basic and Clinical Physiology and Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/jbcpp-2023-0022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
The vestibular system inhibits both HPA and SAM axis and contributes to the management of anxiety. Both direct and indirect pathways exist in the inhibition of the HPA and SAM axis. In this review article, the authors describe various pathways through which the vestibular system can regulate the HPA and SAM axis activity. Lastly, the authors highlight the need of starting translational research work in this field. Rocking is soothing and this is a universal fact that babies in the swing will calm down and sleep. These soothing effects of vestibular stimulation may be due to the inhibition of cortical and subcortical structures. Vestibular stimulation may be able to manage anxiety through its connections with multiple brain areas. There is a need to undertake translational research in this area to establish strong scientific evidence and recommend implementation of the vestibular stimulation in the management of anxiety.
期刊介绍：
The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.
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