The effects of Berberis vulgaris L. root extract on the opiate withdrawal syndrome and psychological factors: a randomized double-blind clinical trial.

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-07-01 DOI:10.1515/jbcpp-2020-0327

Fatemeh Dabaghzadeh, Fariba Sharififar, Amir-Mohammad Ahmadzadeh, Somayyeh Karami-Mohajeri

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引用次数: 1

Abstract

Objectives: In this clinical trial, the effect of aqueous extract of Berberis vulgaris L. was investigated on opiate withdrawal syndrome, depression, anxiety, stress, and sleep quality in opioid addicts which were under methadone maintenance therapy.

Methods: For this purpose, 52 opiate addicts were randomly selected of whom 28 received 500 mg capsules of B. vulgaris extract (treatment) and the rest received 500 mg of starch capsules (placebo), twice daily for 4 weeks. Signs and symptoms of opiate withdrawal syndrome, depression, anxiety, stress, and sleep quality were assessed through Clinical Opiate Withdrawal Scale (COWS), Pittsburgh Sleep Quality Inventory (PSQI) and Depression Anxiety Stress Scales-21 (DASS-21) questionnaires at baseline and after 7, 14, and 28 days of receiving intervention.

Results: Signs and symptoms of opiate withdrawal syndrome were significantly improved in those who received the extract for 1 month compared to the placebo group. However, there were no significant differences in depression, anxiety, stress, and sleep quality scores in the treatment group compared to those in the placebo group.

Conclusions: The extract of B. vulgaris root as a traditional herbal product in combination with methadone could improve the symptoms and signs of opiate withdrawal.

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小檗根提取物对阿片戒断综合征及心理因素的影响:随机双盲临床试验。

目的:研究小檗水提物对接受美沙酮维持治疗的阿片类药物依赖者阿片戒断综合征、抑郁、焦虑、应激及睡眠质量的影响。方法:随机选取52例阿片类成瘾者，其中28例给予寻常草提取物胶囊500 mg(治疗组)，其余给予淀粉胶囊500 mg(安慰剂组)，每日2次，连续4周。通过临床阿片戒断量表(COWS)、匹兹堡睡眠质量量表(PSQI)和抑郁焦虑压力量表-21 (DASS-21)在基线和接受干预后7、14和28天评估阿片戒断综合征的体征和症状、抑郁、焦虑、压力和睡眠质量。结果:与安慰剂组相比，接受提取物1个月的阿片类戒断综合征的体征和症状明显改善。然而，与安慰剂组相比，治疗组在抑郁、焦虑、压力和睡眠质量评分方面没有显著差异。结论:传统中药制剂乌根提取物联合美沙酮可改善阿片戒断症状和体征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.