Development and validation of a nomogram for predicting the risk of vasovagal reactions after plasma donation

IF 1.4 4区医学 Q4 HEMATOLOGY

Journal of Clinical Apheresis Pub Date : 2023-07-19 DOI:10.1002/jca.22074

Peizhe Zhao MS, Demei Dong MD, Rong Dong MD, Yuan Zhou MD, Yan Hong MD, Guanglin Xiao MS, Zhiye Li MS, Xuelin Su BS, Xingyou Zheng BS, Xia Liu BS, Demei Zhang MD, Ling Li MD, Zhong Liu MD

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引用次数: 0

Abstract

Background and Objectives

Vasovagal reactions (VVRs) are the most common adverse reactions and are frequently associated with serious donor adverse events. Even mild VVRs can lead to a significant reduction in the likelihood of subsequent donations. The purpose of this study is to explore the factors related to the occurrence of VVRs after plasma donation and to construct a nomogram to identify individuals at risk for VVRs to improve the safety of plasma donors.

Materials and Methods

We collected the donation data from July 2019 to June 2020 from a plasma center in Sichuan, China, to explore the independent risk factors for vasovagal reactions. From these data, we constructed and validated a predictive model for vasovagal reactions.

Results

VVRs after plasma donation occurred 737 times in 120 448 plasma donations (0.66%). Gender, season, donor status, weight, pulse, duration of donation, and cycle were independent risk factors for VVRs (P< 0.05). The concordance index (C-index) of a logistic model in the derivation cohort was 0.916, with a Hosmer-Lemeshow goodness-of-fit probability of 0.795. The C-index of a logistic model in the validation cohort was 0.916, with a Hosmer-Lemeshow goodness-of-fit probability of 0.224. The calibration curve showed that the predicted results were in good agreement with the actual observed results.

Conclusion

This study preliminarily constructed and verified a prediction model for VVRs after plasma donation. The model nomogram is practical and can identify high-risk donors.

查看原文本刊更多论文

用于预测血浆捐献后血管迷走神经反应风险的列线图的开发和验证。

背景和目的：血管新生血管反应（VVRs）是最常见的不良反应，经常与严重的供体不良事件有关。即使是轻微的VVR也可以显著降低后续捐赠的可能性。本研究的目的是探讨血浆捐献后VVR发生的相关因素，并构建列线图来识别VVR风险个体，以提高血浆捐献者的安全性。材料和方法：我们收集了2019年7月至2020年6月中国四川某血浆中心的捐献数据，以探讨血管迷走神经反应的独立危险因素。根据这些数据，我们构建并验证了血管迷走神经反应的预测模型。结果：120例患者血浆捐献后VVR发生737次 448例血浆捐献（0.66%）。性别、季节、捐献者状态、体重、脉搏、捐献持续时间和周期是VVRs的独立风险因素（P结论：本研究初步构建并验证了血浆捐献后VVRs预测模型。该模型列线图具有实用性，可以识别高危捐献者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Apheresis 医学-血液学

CiteScore

2.80

自引率

13.30%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Clinical Apheresis publishes articles dealing with all aspects of hemapheresis. Articles welcomed for review include those reporting basic research and clinical applications of therapeutic plasma exchange, therapeutic cytapheresis, therapeutic absorption, blood component collection and transfusion, donor recruitment and safety, administration of hemapheresis centers, and innovative applications of hemapheresis technology. Experimental studies, clinical trials, case reports, and concise reviews will be welcomed.