Effects of serotonin transporter and receptor polymorphisms on depression

Revista Colombiana de psiquiatria (English ed.) Pub Date : 2023-04-01 DOI:10.1016/j.rcpeng.2021.07.003

Yéssica P. López-Echeverri, Kelly J. Cardona-Londoño, Jhonny F. Garcia-Aguirre, Mary Orrego-Cardozo

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引用次数: 1

Abstract

Introduction

Serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-HTT, SLC6A4) and the serotonin receptor genes (HTR1A, HTR1B, HTR2A) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics.

Objective

A review of research reports that have studied the effects of variations in the serotonin transporter and receptor genes on different clinical features of depression.

Methods

A search of the Scopus, Web of Science and PubMed databases was conducted using the keywords ("depression" AND "polymorphism").

Conclusions

According to the review of 54 articles, the short allele of the 5-HTTLPR polymorphism was found to be the most reported risk factor related to the development of depression and its severity. Variations in the genes studied (SLC6A4, HTR1A, HTR2A) can generate morphological alterations of brain structures.

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血清素转运体和受体多态性对抑郁症的影响

引言血清素与情绪状态的调节和认知任务的执行密切相关，因此血清素转运蛋白基因（5-HTT、SLC6A4）和血清素受体基因（HTR1A、HTR1B、HTR2A）已成为研究这些基因及其多态性变异对抑郁症特征影响的完美候选者。目的综述研究血清素转运蛋白和受体基因变异对抑郁症不同临床特征的影响的研究报告。方法检索Scopus、Web of Science和PubMed数据库，关键词为“抑郁症”和“多态性”。所研究的基因（SLC6A4、HTR1A、HTR2A）的变异可以引起大脑结构的形态学改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista Colombiana de psiquiatria (English ed.)

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